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Utility of gallium67 scintigraphy and bronchial washings in the diagnosis and treatment of Pneumocystis carinii pneumonia in patients with the acquired immune deficiency syndrome.
Am Rev Respir Dis. 1985 Nov; 132(5):1087-92.AR

Abstract

Twenty patients with the acquired immune deficiency syndrome (AIDS) and suspected Pneumocystis carinii pneumonia were evaluated by gallium67 (Ga67 scintigraphy and fiberoptic bronchoscopy for initial diagnosis and response to therapy. Lung uptake of Ga67 was demonstrated in 100% of AIDS patients with P. carinii pneumonia, including those with subclinical infection. Fiberoptic bronchoscopy identified P. carinii in the bronchial washings of 100% of cases (19 patients), whereas only 13 of 16 (81%) patients had P. carinii in lung tissue obtained by transbronchial biopsy. Repeat fiberoptic bronchoscopy was performed in 16 of 20 patients. After 2 to 4 wk of therapy, P. carinii was identified in bronchial washings in 8 of 16 (50%) patients and in transbronchial biopsy in 1 of 10 (10%) patients examined. Bronchial washing has a higher yield than transbronchial biopsy in demonstrating P. carinii in patients with AIDS and may evolve as the procedure of choice in such patients. Based on the clinical course and results of Ga67 scintigraphy and fiberoptic bronchoscopy in AIDS patients with P. carinii pneumonia, optimal therapy may require at least 3 wk of treatment.

Authors

Tuazon CU
No affiliation info available
Delaney MD
No affiliation info available
Simon GL
No affiliation info available
Witorsch P
No affiliation info available
Varma VM
No affiliation info available

MeSH

Acquired Immunodeficiency SyndromeAdultBiopsyBronchiBronchoscopyDrug CombinationsGallium RadioisotopesHumansMiddle AgedPentamidinePneumocystisPneumonia, PneumocystisRadionuclide ImagingSulfamethoxazoleTrimethoprimTrimethoprim, Sulfamethoxazole Drug Combination

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3877481

Citation

Tuazon, C U., et al. "Utility of Gallium67 Scintigraphy and Bronchial Washings in the Diagnosis and Treatment of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immune Deficiency Syndrome." The American Review of Respiratory Disease, vol. 132, no. 5, 1985, pp. 1087-92.
Tuazon CU, Delaney MD, Simon GL, et al. Utility of gallium67 scintigraphy and bronchial washings in the diagnosis and treatment of Pneumocystis carinii pneumonia in patients with the acquired immune deficiency syndrome. Am Rev Respir Dis. 1985;132(5):1087-92.
Tuazon, C. U., Delaney, M. D., Simon, G. L., Witorsch, P., & Varma, V. M. (1985). Utility of gallium67 scintigraphy and bronchial washings in the diagnosis and treatment of Pneumocystis carinii pneumonia in patients with the acquired immune deficiency syndrome. The American Review of Respiratory Disease, 132(5), 1087-92.
Tuazon CU, et al. Utility of Gallium67 Scintigraphy and Bronchial Washings in the Diagnosis and Treatment of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immune Deficiency Syndrome. Am Rev Respir Dis. 1985;132(5):1087-92. PubMed PMID: 3877481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Utility of gallium67 scintigraphy and bronchial washings in the diagnosis and treatment of Pneumocystis carinii pneumonia in patients with the acquired immune deficiency syndrome. AU - Tuazon,C U, AU - Delaney,M D, AU - Simon,G L, AU - Witorsch,P, AU - Varma,V M, PY - 1985/11/1/pubmed PY - 1985/11/1/medline PY - 1985/11/1/entrez SP - 1087 EP - 92 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 132 IS - 5 N2 - Twenty patients with the acquired immune deficiency syndrome (AIDS) and suspected Pneumocystis carinii pneumonia were evaluated by gallium67 (Ga67 scintigraphy and fiberoptic bronchoscopy for initial diagnosis and response to therapy. Lung uptake of Ga67 was demonstrated in 100% of AIDS patients with P. carinii pneumonia, including those with subclinical infection. Fiberoptic bronchoscopy identified P. carinii in the bronchial washings of 100% of cases (19 patients), whereas only 13 of 16 (81%) patients had P. carinii in lung tissue obtained by transbronchial biopsy. Repeat fiberoptic bronchoscopy was performed in 16 of 20 patients. After 2 to 4 wk of therapy, P. carinii was identified in bronchial washings in 8 of 16 (50%) patients and in transbronchial biopsy in 1 of 10 (10%) patients examined. Bronchial washing has a higher yield than transbronchial biopsy in demonstrating P. carinii in patients with AIDS and may evolve as the procedure of choice in such patients. Based on the clinical course and results of Ga67 scintigraphy and fiberoptic bronchoscopy in AIDS patients with P. carinii pneumonia, optimal therapy may require at least 3 wk of treatment. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/3877481/Utility_of_gallium67_scintigraphy_and_bronchial_washings_in_the_diagnosis_and_treatment_of_Pneumocystis_carinii_pneumonia_in_patients_with_the_acquired_immune_deficiency_syndrome_ DB - PRIME DP - Unbound Medicine ER -