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HLA-B27 and ankylosing spondylitis: an anti-idiotypic model.
J Clin Lab Immunol. 1985 Nov; 18(3):123-7.JC

Abstract

Ankylosing spondylitis (AS) is strongly associated with possession of the HLA (Human Leucocyte Antigen)-B27 histocompatibility alloantigen. It is proposed that immunological tolerance to HLA-B27 allows the emergence of a lymphocyte clone with specificity for connective tissue antigens. Such a pathogenic clone would possess idiotypic determinants cross-reactive with determinants on HLA-B27. This hypothesis was investigated using immunoglobulins from HLA-B27 subjects with active definite AS. Immunoglobulin fractions were assayed for HLA-B27-like idiotopes by inhibition of the cytotoxicity of an anti-HLA-B27 antiserum, and by an ELISA technique. The postulated HLA-B27-like idiotope was not detected using these methods.

Authors

McLean IL
No affiliation info available
Adams DD
No affiliation info available
Highton J
No affiliation info available

MeSH

AdultAntibodies, Anti-IdiotypicClone CellsCytotoxicity, ImmunologicHLA AntigensHLA-B27 AntigenHumansImmune ToleranceImmunoglobulin IdiotypesLymphocytesMaleModels, BiologicalSpondylitis, Ankylosing

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3878886

Citation

McLean, I L., et al. "HLA-B27 and Ankylosing Spondylitis: an Anti-idiotypic Model." Journal of Clinical & Laboratory Immunology, vol. 18, no. 3, 1985, pp. 123-7.
McLean IL, Adams DD, Highton J. HLA-B27 and ankylosing spondylitis: an anti-idiotypic model. J Clin Lab Immunol. 1985;18(3):123-7.
McLean, I. L., Adams, D. D., & Highton, J. (1985). HLA-B27 and ankylosing spondylitis: an anti-idiotypic model. Journal of Clinical & Laboratory Immunology, 18(3), 123-7.
McLean IL, Adams DD, Highton J. HLA-B27 and Ankylosing Spondylitis: an Anti-idiotypic Model. J Clin Lab Immunol. 1985;18(3):123-7. PubMed PMID: 3878886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-B27 and ankylosing spondylitis: an anti-idiotypic model. AU - McLean,I L, AU - Adams,D D, AU - Highton,J, PY - 1985/11/1/pubmed PY - 1985/11/1/medline PY - 1985/11/1/entrez SP - 123 EP - 7 JF - Journal of clinical & laboratory immunology JO - J Clin Lab Immunol VL - 18 IS - 3 N2 - Ankylosing spondylitis (AS) is strongly associated with possession of the HLA (Human Leucocyte Antigen)-B27 histocompatibility alloantigen. It is proposed that immunological tolerance to HLA-B27 allows the emergence of a lymphocyte clone with specificity for connective tissue antigens. Such a pathogenic clone would possess idiotypic determinants cross-reactive with determinants on HLA-B27. This hypothesis was investigated using immunoglobulins from HLA-B27 subjects with active definite AS. Immunoglobulin fractions were assayed for HLA-B27-like idiotopes by inhibition of the cytotoxicity of an anti-HLA-B27 antiserum, and by an ELISA technique. The postulated HLA-B27-like idiotope was not detected using these methods. SN - 0141-2760 UR - https://www.unboundmedicine.com/medline/citation/3878886/HLA_B27_and_ankylosing_spondylitis:_an_anti_idiotypic_model_ DB - PRIME DP - Unbound Medicine ER -