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Insulin pump treatment: effect on glucose homeostasis, metabolites, hormones, insulin antibodies and quality of life.
Diabetes Res. 1985 Jan; 2(1):37-43.DR

Abstract

Continuous subcutaneous insulin infusion (CSII) with a portable pump was compared to unchanged conventional treatment (UCT) in long-term treated patients with IDDM in order to evaluate changes in glucose homeostasis, metabolites, hormones and quality of life. We found that the mean blood glucose values, measured at home, and the HbA1c values were significantly lower in the CSII group compared to the UCT group. The improved control during CSII was followed by a nearly normalization of the diurnal pattern of FFA and ketone bodies in plasma. Plasma free insulin values were significantly higher in the morning (fasting) during CSII compared to UCT, whereas the mean diurnal concentrations and the diurnal pattern were identical in the 2 groups. Both peak values of growth hormone during the day and the fasting values were significantly lower in the CSII group compared to the UCT group. In patients treated with the insulin pump (CSII) the wellbeing (quality of life) was estimated to be significantly improved. Two patients developed ketoacidosis during CSII, whereas 2 controls (UCT) were hospitalized with hypoglycemic coma. We conclude that insulin pump treatment for 6 months results in a near normalization of glucose and FFA metabolism, resulting in an improved quality of life. The improved control seems not to be explained by a change of the diurnal pattern of plasma insulin. However, the higher morning values may be of significant importance.

Authors

Beck-Nielsen H
No affiliation info available
Richelsen B
No affiliation info available
Schwartz Sørensen N
No affiliation info available
Hother Nielsen O
No affiliation info available

MeSH

AdultAntibodiesBlood GlucoseDiabetes Mellitus, Type 1Evaluation Studies as TopicFatty Acids, NonesterifiedFemaleGrowth HormoneHumansInsulinInsulin Infusion SystemsMaleQuality of Life

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3888495

Citation

Beck-Nielsen, H, et al. "Insulin Pump Treatment: Effect On Glucose Homeostasis, Metabolites, Hormones, Insulin Antibodies and Quality of Life." Diabetes Research (Edinburgh, Scotland), vol. 2, no. 1, 1985, pp. 37-43.
Beck-Nielsen H, Richelsen B, Schwartz Sørensen N, et al. Insulin pump treatment: effect on glucose homeostasis, metabolites, hormones, insulin antibodies and quality of life. Diabetes Res. 1985;2(1):37-43.
Beck-Nielsen, H., Richelsen, B., Schwartz Sørensen, N., & Hother Nielsen, O. (1985). Insulin pump treatment: effect on glucose homeostasis, metabolites, hormones, insulin antibodies and quality of life. Diabetes Research (Edinburgh, Scotland), 2(1), 37-43.
Beck-Nielsen H, et al. Insulin Pump Treatment: Effect On Glucose Homeostasis, Metabolites, Hormones, Insulin Antibodies and Quality of Life. Diabetes Res. 1985;2(1):37-43. PubMed PMID: 3888495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin pump treatment: effect on glucose homeostasis, metabolites, hormones, insulin antibodies and quality of life. AU - Beck-Nielsen,H, AU - Richelsen,B, AU - Schwartz Sørensen,N, AU - Hother Nielsen,O, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 37 EP - 43 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res VL - 2 IS - 1 N2 - Continuous subcutaneous insulin infusion (CSII) with a portable pump was compared to unchanged conventional treatment (UCT) in long-term treated patients with IDDM in order to evaluate changes in glucose homeostasis, metabolites, hormones and quality of life. We found that the mean blood glucose values, measured at home, and the HbA1c values were significantly lower in the CSII group compared to the UCT group. The improved control during CSII was followed by a nearly normalization of the diurnal pattern of FFA and ketone bodies in plasma. Plasma free insulin values were significantly higher in the morning (fasting) during CSII compared to UCT, whereas the mean diurnal concentrations and the diurnal pattern were identical in the 2 groups. Both peak values of growth hormone during the day and the fasting values were significantly lower in the CSII group compared to the UCT group. In patients treated with the insulin pump (CSII) the wellbeing (quality of life) was estimated to be significantly improved. Two patients developed ketoacidosis during CSII, whereas 2 controls (UCT) were hospitalized with hypoglycemic coma. We conclude that insulin pump treatment for 6 months results in a near normalization of glucose and FFA metabolism, resulting in an improved quality of life. The improved control seems not to be explained by a change of the diurnal pattern of plasma insulin. However, the higher morning values may be of significant importance. SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/3888495/Insulin_pump_treatment:_effect_on_glucose_homeostasis_metabolites_hormones_insulin_antibodies_and_quality_of_life_ DB - PRIME DP - Unbound Medicine ER -