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Incidence of hypoglycemic episodes in diabetic patients under continuous subcutaneous insulin infusion and intensified conventional insulin treatment: assessment by means of semiambulatory 24-hour continuous blood glucose monitoring.
Diabetes Care. 1985 Mar-Apr; 8(2):134-40.DC

Abstract

The incidence and magnitude of hypoglycemia (i.e., blood glucose values less than 50 mg/dl) were assessed by continuous blood glucose monitoring over 24 h in 10 insulin-dependent diabetic (IDD) patients treated with continuous subcutaneous insulin infusion (CSII) and 9 IDD patients under intensified conventional treatment (ICT). A newly developed, battery-powered blood glucose monitor was employed. Patients were thus enabled to move freely in the hospital premises. Despite similar quality of previous blood glucose control (HbA1: 8.0 +/- 0.05% CSII versus 8.0 +/- 0.3% ICT, mean +/- SEM), the obtained profiles showed better regulation under CSII treatment (mean blood glucose [MBG], 99.6 +/- 10.0 versus 133.1 +/- 7.4 mg/dl; M-value, 12.3 +/- 3.5 versus 26.2 +/- 4.1; mean amplitude of glycemic excursion [MAGE], 71.9 +/- 8.7 versus 132.9 +/- 14.2 mg/dl; CSII versus ICT, mean +/- SEM). The incidence of blood glucose values less than 50 mg/dl was 9/10 patients (CSII) and 5/9 patients (ICT). In both groups, hypoglycemia was most frequent at noon and was related to elevated pre- and postprandial free insulin levels. Patients became aware of hypoglycemia only in 6/23 episodes (CSII) and 6/8 episodes (ICT). Our data indicate that CSII as well as ICT may result in postprandial hyperinsulinemia leading to frequent hypoglycemic episodes of variable length, reassessing the traditional experience of close correlation between aggressive insulin therapy and enhanced hypoglycemic risk.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3888562

Citation

Arias, P, et al. "Incidence of Hypoglycemic Episodes in Diabetic Patients Under Continuous Subcutaneous Insulin Infusion and Intensified Conventional Insulin Treatment: Assessment By Means of Semiambulatory 24-hour Continuous Blood Glucose Monitoring." Diabetes Care, vol. 8, no. 2, 1985, pp. 134-40.
Arias P, Kerner W, Zier H, et al. Incidence of hypoglycemic episodes in diabetic patients under continuous subcutaneous insulin infusion and intensified conventional insulin treatment: assessment by means of semiambulatory 24-hour continuous blood glucose monitoring. Diabetes Care. 1985;8(2):134-40.
Arias, P., Kerner, W., Zier, H., Navascués, I., & Pfeiffer, E. F. (1985). Incidence of hypoglycemic episodes in diabetic patients under continuous subcutaneous insulin infusion and intensified conventional insulin treatment: assessment by means of semiambulatory 24-hour continuous blood glucose monitoring. Diabetes Care, 8(2), 134-40.
Arias P, et al. Incidence of Hypoglycemic Episodes in Diabetic Patients Under Continuous Subcutaneous Insulin Infusion and Intensified Conventional Insulin Treatment: Assessment By Means of Semiambulatory 24-hour Continuous Blood Glucose Monitoring. Diabetes Care. 1985 Mar-Apr;8(2):134-40. PubMed PMID: 3888562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of hypoglycemic episodes in diabetic patients under continuous subcutaneous insulin infusion and intensified conventional insulin treatment: assessment by means of semiambulatory 24-hour continuous blood glucose monitoring. AU - Arias,P, AU - Kerner,W, AU - Zier,H, AU - Navascués,I, AU - Pfeiffer,E F, PY - 1985/3/1/pubmed PY - 1985/3/1/medline PY - 1985/3/1/entrez SP - 134 EP - 40 JF - Diabetes care JO - Diabetes Care VL - 8 IS - 2 N2 - The incidence and magnitude of hypoglycemia (i.e., blood glucose values less than 50 mg/dl) were assessed by continuous blood glucose monitoring over 24 h in 10 insulin-dependent diabetic (IDD) patients treated with continuous subcutaneous insulin infusion (CSII) and 9 IDD patients under intensified conventional treatment (ICT). A newly developed, battery-powered blood glucose monitor was employed. Patients were thus enabled to move freely in the hospital premises. Despite similar quality of previous blood glucose control (HbA1: 8.0 +/- 0.05% CSII versus 8.0 +/- 0.3% ICT, mean +/- SEM), the obtained profiles showed better regulation under CSII treatment (mean blood glucose [MBG], 99.6 +/- 10.0 versus 133.1 +/- 7.4 mg/dl; M-value, 12.3 +/- 3.5 versus 26.2 +/- 4.1; mean amplitude of glycemic excursion [MAGE], 71.9 +/- 8.7 versus 132.9 +/- 14.2 mg/dl; CSII versus ICT, mean +/- SEM). The incidence of blood glucose values less than 50 mg/dl was 9/10 patients (CSII) and 5/9 patients (ICT). In both groups, hypoglycemia was most frequent at noon and was related to elevated pre- and postprandial free insulin levels. Patients became aware of hypoglycemia only in 6/23 episodes (CSII) and 6/8 episodes (ICT). Our data indicate that CSII as well as ICT may result in postprandial hyperinsulinemia leading to frequent hypoglycemic episodes of variable length, reassessing the traditional experience of close correlation between aggressive insulin therapy and enhanced hypoglycemic risk. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/3888562/Incidence_of_hypoglycemic_episodes_in_diabetic_patients_under_continuous_subcutaneous_insulin_infusion_and_intensified_conventional_insulin_treatment:_assessment_by_means_of_semiambulatory_24_hour_continuous_blood_glucose_monitoring_ L2 - https://medlineplus.gov/hypoglycemia.html DB - PRIME DP - Unbound Medicine ER -