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Leprosy in a mangabey monkey--naturally acquired infection.
Int J Lepr Other Mycobact Dis. 1985 Mar; 53(1):1-14.IJ

Abstract

Naturally acquired leprosy was detected in an otherwise normal "sooty" mangabey monkey (Cercocebus atys). This animal was imported from West Africa in 1975 and developed clinical symptoms of leprosy in 1979. Histopathologic findings were those of subpolar-lepromatous to borderline-lepromatous leprosy in the Ridley-Jopling classification. The disease was progressive, with crippling neuropathic deformities of the hands and feet. The disease regressed under specific therapy. The etiologic agent was identified as Mycobacterium leprae by the following criteria: invasion of nerves of host, staining properties, electron microscopic findings, noncultivable on mycobacteriologic media, DOPA-oxidase positive, lepromin reactivity, infection patterns in mice and armadillos, sensitivity to sulfone, and DNA homology. We believe the animal acquired the disease from a patient with active leprosy. The mangabey monkey offers promise as a primate model for leprosy, and adds a third reported species to animals with naturally acquired leprosy.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3889184

Citation

Meyers, W M., et al. "Leprosy in a Mangabey Monkey--naturally Acquired Infection." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 53, no. 1, 1985, pp. 1-14.
Meyers WM, Walsh GP, Brown HL, et al. Leprosy in a mangabey monkey--naturally acquired infection. Int J Lepr Other Mycobact Dis. 1985;53(1):1-14.
Meyers, W. M., Walsh, G. P., Brown, H. L., Binford, C. H., Imes, G. D., Hadfield, T. L., Schlagel, C. J., Fukunishi, Y., Gerone, P. J., & Wolf, R. H. (1985). Leprosy in a mangabey monkey--naturally acquired infection. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 53(1), 1-14.
Meyers WM, et al. Leprosy in a Mangabey Monkey--naturally Acquired Infection. Int J Lepr Other Mycobact Dis. 1985;53(1):1-14. PubMed PMID: 3889184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leprosy in a mangabey monkey--naturally acquired infection. A1 - Meyers,W M, AU - Walsh,G P, AU - Brown,H L, AU - Binford,C H, AU - Imes,G D,Jr AU - Hadfield,T L, AU - Schlagel,C J, AU - Fukunishi,Y, AU - Gerone,P J, AU - Wolf,R H, PY - 1985/3/1/pubmed PY - 2001/3/28/medline PY - 1985/3/1/entrez SP - 1 EP - 14 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 53 IS - 1 N2 - Naturally acquired leprosy was detected in an otherwise normal "sooty" mangabey monkey (Cercocebus atys). This animal was imported from West Africa in 1975 and developed clinical symptoms of leprosy in 1979. Histopathologic findings were those of subpolar-lepromatous to borderline-lepromatous leprosy in the Ridley-Jopling classification. The disease was progressive, with crippling neuropathic deformities of the hands and feet. The disease regressed under specific therapy. The etiologic agent was identified as Mycobacterium leprae by the following criteria: invasion of nerves of host, staining properties, electron microscopic findings, noncultivable on mycobacteriologic media, DOPA-oxidase positive, lepromin reactivity, infection patterns in mice and armadillos, sensitivity to sulfone, and DNA homology. We believe the animal acquired the disease from a patient with active leprosy. The mangabey monkey offers promise as a primate model for leprosy, and adds a third reported species to animals with naturally acquired leprosy. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/3889184/Leprosy_in_a_mangabey_monkey__naturally_acquired_infection_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -