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Electron microscopic findings of the peripheral nerve lesions of nude mice inoculated with M. leprae.
Int J Lepr Other Mycobact Dis. 1985 Mar; 53(1):75-8.IJ

Abstract

Peripheral nerve lesions of nude mice inoculated with Mycobacterium leprae were examined from 1 year to 1 year and 8 months post-inoculation. Leprosy bacilli and intracytoplasmic foamy structures were found in the perineurial cells, endothelial cells of capillaries, Schwann cells, and axons of the myelinated nerve fibers inside the lepromas of foot pads. In the proximal portion of the sciatic nerve, bacilli were found chiefly in the macrophages of the endoneurial space. Bacilli were not found in the perineurial cells of the sciatic nerves. Marked fibrosis, hypertrophy or degeneration of Schwann cells, demyelination, axonal damage or irreversible destruction of nerve architecture were not observed clearly. Therefore, it is thought that nude mice inoculated with M. leprae are suitable models for the study of the early peripheral nerve lesions of lepromatous leprosy.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3889194

Citation

Fukunishi, Y. "Electron Microscopic Findings of the Peripheral Nerve Lesions of Nude Mice Inoculated With M. Leprae." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 53, no. 1, 1985, pp. 75-8.
Fukunishi Y. Electron microscopic findings of the peripheral nerve lesions of nude mice inoculated with M. leprae. Int J Lepr Other Mycobact Dis. 1985;53(1):75-8.
Fukunishi, Y. (1985). Electron microscopic findings of the peripheral nerve lesions of nude mice inoculated with M. leprae. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 53(1), 75-8.
Fukunishi Y. Electron Microscopic Findings of the Peripheral Nerve Lesions of Nude Mice Inoculated With M. Leprae. Int J Lepr Other Mycobact Dis. 1985;53(1):75-8. PubMed PMID: 3889194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electron microscopic findings of the peripheral nerve lesions of nude mice inoculated with M. leprae. A1 - Fukunishi,Y, PY - 1985/3/1/pubmed PY - 1985/3/1/medline PY - 1985/3/1/entrez SP - 75 EP - 8 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 53 IS - 1 N2 - Peripheral nerve lesions of nude mice inoculated with Mycobacterium leprae were examined from 1 year to 1 year and 8 months post-inoculation. Leprosy bacilli and intracytoplasmic foamy structures were found in the perineurial cells, endothelial cells of capillaries, Schwann cells, and axons of the myelinated nerve fibers inside the lepromas of foot pads. In the proximal portion of the sciatic nerve, bacilli were found chiefly in the macrophages of the endoneurial space. Bacilli were not found in the perineurial cells of the sciatic nerves. Marked fibrosis, hypertrophy or degeneration of Schwann cells, demyelination, axonal damage or irreversible destruction of nerve architecture were not observed clearly. Therefore, it is thought that nude mice inoculated with M. leprae are suitable models for the study of the early peripheral nerve lesions of lepromatous leprosy. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/3889194/Electron_microscopic_findings_of_the_peripheral_nerve_lesions_of_nude_mice_inoculated_with_M__leprae_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -