Tags

Type your tag names separated by a space and hit enter

Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages.
Immunology. 1985 Jul; 55(3):489-500.I

Abstract

A panel of monoclonal antibodies to monomorphic determinants of the MHC class II subregion locus products: DP, DR and DQ, was used to investigate the expression of these antigens on early lymphocytes and macrophages from human fetal liver (13-20 weeks), placenta (16 weeks and term) and cord blood, in relation to the class II phenotype of cells from adult tonsil and peripheral blood. Fetal liver sections and cell suspensions showed differential expression of class II antigens. DP was expressed at a higher frequency (11.0% of nucleated cells) than DR on lymphoid cells and macrophages from fetal liver, and DQ was either absent or expressed on less than 0.3% of nucleated cells. Consistent with this finding, DP but not DR or DQ antigens were observed on vascular elements and macrophages in the villi of 16-week placenta. At term, all three subregion locus products were expressed. Adult tonsil and peripheral blood B lymphocytes expressed DP, DR and DQ antigens with similar frequency; however, DQ was expressed at a lower frequency than DP and DR on cord blood B lymphocytes. In contrast, 30-50% macrophages from cord blood and adult peripheral blood expressed DP and DR, but fewer (5% and 18%, respectively) expressed DQ. These data suggest that class II antigens are expressed in the sequence DP, DR, DQ on developing lymphocytes. A similar sequence is suggested for macrophages.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3894221

Citation

Edwards, J A., et al. "Differential Expression of HLA Class II Antigens On Human Fetal and Adult Lymphocytes and Macrophages." Immunology, vol. 55, no. 3, 1985, pp. 489-500.
Edwards JA, Jones DB, Evans PR, et al. Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. Immunology. 1985;55(3):489-500.
Edwards, J. A., Jones, D. B., Evans, P. R., & Smith, J. L. (1985). Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. Immunology, 55(3), 489-500.
Edwards JA, et al. Differential Expression of HLA Class II Antigens On Human Fetal and Adult Lymphocytes and Macrophages. Immunology. 1985;55(3):489-500. PubMed PMID: 3894221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. AU - Edwards,J A, AU - Jones,D B, AU - Evans,P R, AU - Smith,J L, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 489 EP - 500 JF - Immunology JO - Immunology VL - 55 IS - 3 N2 - A panel of monoclonal antibodies to monomorphic determinants of the MHC class II subregion locus products: DP, DR and DQ, was used to investigate the expression of these antigens on early lymphocytes and macrophages from human fetal liver (13-20 weeks), placenta (16 weeks and term) and cord blood, in relation to the class II phenotype of cells from adult tonsil and peripheral blood. Fetal liver sections and cell suspensions showed differential expression of class II antigens. DP was expressed at a higher frequency (11.0% of nucleated cells) than DR on lymphoid cells and macrophages from fetal liver, and DQ was either absent or expressed on less than 0.3% of nucleated cells. Consistent with this finding, DP but not DR or DQ antigens were observed on vascular elements and macrophages in the villi of 16-week placenta. At term, all three subregion locus products were expressed. Adult tonsil and peripheral blood B lymphocytes expressed DP, DR and DQ antigens with similar frequency; however, DQ was expressed at a lower frequency than DP and DR on cord blood B lymphocytes. In contrast, 30-50% macrophages from cord blood and adult peripheral blood expressed DP and DR, but fewer (5% and 18%, respectively) expressed DQ. These data suggest that class II antigens are expressed in the sequence DP, DR, DQ on developing lymphocytes. A similar sequence is suggested for macrophages. SN - 0019-2805 UR - https://www.unboundmedicine.com/medline/citation/3894221/Differential_expression_of_HLA_class_II_antigens_on_human_fetal_and_adult_lymphocytes_and_macrophages_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3894221/ DB - PRIME DP - Unbound Medicine ER -