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High performance liquid chromatography used to distinguish the autoimmune hypoglycemia syndrome from factitious hypoglycemia.
J Clin Endocrinol Metab. 1985 Sep; 61(3):571-4.JC

Abstract

Recurrent episodes of spontaneous hypoglycemia developed in a 30-yr-old woman who had received a brief course of insulin therapy 10 yr previously. She denied surreptitious insulin administration, and the autoimmune hypoglycemia syndrome was considered. Her insulin levels could not be reliably measured because of the presence of circulating antiinsulin antibodies, which interfere with standard RIA techniques. Reverse phase high performance liquid chromatographic analysis of serum obtained during a hypoglycemic episode revealed a mixture of beef and pork insulins but no human insulin, firmly establishing the diagnosis of factitious hypoglycemia. This case illustrates the value of reverse phase high performance liquid chromatography in characterizing patients in whom the autoimmune hypoglycemia syndrome is suspected.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3894407

Citation

Klein, R F., et al. "High Performance Liquid Chromatography Used to Distinguish the Autoimmune Hypoglycemia Syndrome From Factitious Hypoglycemia." The Journal of Clinical Endocrinology and Metabolism, vol. 61, no. 3, 1985, pp. 571-4.
Klein RF, Seino S, Sanz N, et al. High performance liquid chromatography used to distinguish the autoimmune hypoglycemia syndrome from factitious hypoglycemia. J Clin Endocrinol Metab. 1985;61(3):571-4.
Klein, R. F., Seino, S., Sanz, N., Nolte, M. S., Vinik, A. I., & Karam, J. H. (1985). High performance liquid chromatography used to distinguish the autoimmune hypoglycemia syndrome from factitious hypoglycemia. The Journal of Clinical Endocrinology and Metabolism, 61(3), 571-4.
Klein RF, et al. High Performance Liquid Chromatography Used to Distinguish the Autoimmune Hypoglycemia Syndrome From Factitious Hypoglycemia. J Clin Endocrinol Metab. 1985;61(3):571-4. PubMed PMID: 3894407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High performance liquid chromatography used to distinguish the autoimmune hypoglycemia syndrome from factitious hypoglycemia. AU - Klein,R F, AU - Seino,S, AU - Sanz,N, AU - Nolte,M S, AU - Vinik,A I, AU - Karam,J H, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 571 EP - 4 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 61 IS - 3 N2 - Recurrent episodes of spontaneous hypoglycemia developed in a 30-yr-old woman who had received a brief course of insulin therapy 10 yr previously. She denied surreptitious insulin administration, and the autoimmune hypoglycemia syndrome was considered. Her insulin levels could not be reliably measured because of the presence of circulating antiinsulin antibodies, which interfere with standard RIA techniques. Reverse phase high performance liquid chromatographic analysis of serum obtained during a hypoglycemic episode revealed a mixture of beef and pork insulins but no human insulin, firmly establishing the diagnosis of factitious hypoglycemia. This case illustrates the value of reverse phase high performance liquid chromatography in characterizing patients in whom the autoimmune hypoglycemia syndrome is suspected. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/3894407/High_performance_liquid_chromatography_used_to_distinguish_the_autoimmune_hypoglycemia_syndrome_from_factitious_hypoglycemia_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-61-3-571 DB - PRIME DP - Unbound Medicine ER -