Tags

Type your tag names separated by a space and hit enter

Isolation of characteristic glycolipids possibly included in spherical droplets around M. leprae.
Int J Lepr Other Mycobact Dis. 1985 Sep; 53(3):447-54.IJ

Abstract

The main purpose of this work was to isolate the components in acetone soluble lipids of lepromas of the nine-banded armadillo by high performance liquid chromatography (HPLC), and then to examine the mass spectrometric characteristics of the two peaks (molecular weights 2000 and 1600) found by HPLC. The armadillo had been inoculated with Mycobacterium leprae isolated from a mangabey monkey with naturally acquired leprosy. According to the results of HPLC, gas liquid chromatographic and mass spectral analyses, the GPC peak I lipid at 2000 D was identified as phenolic glycolipid and the GPC peak II lipid at 1600 D, as phthiocerol dimycocerosate. It was thought that the GPC peak I lipid and the GPC peak II lipid were included in the spherical droplets (peribacillary substance) around M. leprae. It was concluded that the microorganisms causing leprosy-like changes in the mangabey monkey were either M. leprae or a very closely related bacillus.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3900252

Citation

Fukunishi, Y, et al. "Isolation of Characteristic Glycolipids Possibly Included in Spherical Droplets Around M. Leprae." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 53, no. 3, 1985, pp. 447-54.
Fukunishi Y, Kearney GP, Whiting J, et al. Isolation of characteristic glycolipids possibly included in spherical droplets around M. leprae. Int J Lepr Other Mycobact Dis. 1985;53(3):447-54.
Fukunishi, Y., Kearney, G. P., Whiting, J., Walsh, G. P., Meyers, W. M., & Johnson, F. B. (1985). Isolation of characteristic glycolipids possibly included in spherical droplets around M. leprae. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 53(3), 447-54.
Fukunishi Y, et al. Isolation of Characteristic Glycolipids Possibly Included in Spherical Droplets Around M. Leprae. Int J Lepr Other Mycobact Dis. 1985;53(3):447-54. PubMed PMID: 3900252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of characteristic glycolipids possibly included in spherical droplets around M. leprae. AU - Fukunishi,Y, AU - Kearney,G P, AU - Whiting,J,Jr AU - Walsh,G P, AU - Meyers,W M, AU - Johnson,F B, PY - 1985/9/1/pubmed PY - 2001/3/28/medline PY - 1985/9/1/entrez SP - 447 EP - 54 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 53 IS - 3 N2 - The main purpose of this work was to isolate the components in acetone soluble lipids of lepromas of the nine-banded armadillo by high performance liquid chromatography (HPLC), and then to examine the mass spectrometric characteristics of the two peaks (molecular weights 2000 and 1600) found by HPLC. The armadillo had been inoculated with Mycobacterium leprae isolated from a mangabey monkey with naturally acquired leprosy. According to the results of HPLC, gas liquid chromatographic and mass spectral analyses, the GPC peak I lipid at 2000 D was identified as phenolic glycolipid and the GPC peak II lipid at 1600 D, as phthiocerol dimycocerosate. It was thought that the GPC peak I lipid and the GPC peak II lipid were included in the spherical droplets (peribacillary substance) around M. leprae. It was concluded that the microorganisms causing leprosy-like changes in the mangabey monkey were either M. leprae or a very closely related bacillus. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/3900252/Isolation_of_characteristic_glycolipids_possibly_included_in_spherical_droplets_around_M__leprae_ DB - PRIME DP - Unbound Medicine ER -