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Antihyperuricemic properties of amflutizole in gout.
J Rheumatol. 1985 Jun; 12(3):540-3.JR

Abstract

The antihyperuricemic properties of amflutizole were investigated in studies designed to determine its efficacy and mechanisms of action in individuals with gout and hyperuricemia. In a randomized double blind, multiple dose, crossover study of 29 patients, amflutizole caused a significant dose dependent reduction in serum urate concentrations. Mean serum urate concentrations decreased significantly from 9.6 +/- 1.5 mg/dl to 7.2 +/- 1.3 mg/dl with the 500 mg dosage (p less than 0.01). Detailed studies in 5 patients demonstrated evidence for modest xanthine oxidase inhibition. However, the majority of the antihyperuricemic effect was derived from an enhanced renal clearance of uric acid. Although the drug has significant antihyperuricemic properties, these were inadequate to achieve adequate control of the serum urate concentration in hyperuricemia and gout at the doses utilized.

Authors

Wortmann RL
No affiliation info available
Ridolfo AS
No affiliation info available
Lightfoot RW
No affiliation info available
Fox IH
No affiliation info available

MeSH

AdultAgedArthritisClinical Trials as TopicDose-Response Relationship, DrugDrug ToleranceFemaleGoutGout SuppressantsHumansKidneyMaleMiddle AgedRandom AllocationThiazolesUric AcidXanthine Oxidase

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3900392

Citation

Wortmann, R L., et al. "Antihyperuricemic Properties of Amflutizole in Gout." The Journal of Rheumatology, vol. 12, no. 3, 1985, pp. 540-3.
Wortmann RL, Ridolfo AS, Lightfoot RW, et al. Antihyperuricemic properties of amflutizole in gout. J Rheumatol. 1985;12(3):540-3.
Wortmann, R. L., Ridolfo, A. S., Lightfoot, R. W., & Fox, I. H. (1985). Antihyperuricemic properties of amflutizole in gout. The Journal of Rheumatology, 12(3), 540-3.
Wortmann RL, et al. Antihyperuricemic Properties of Amflutizole in Gout. J Rheumatol. 1985;12(3):540-3. PubMed PMID: 3900392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperuricemic properties of amflutizole in gout. AU - Wortmann,R L, AU - Ridolfo,A S, AU - Lightfoot,R W,Jr AU - Fox,I H, PY - 1985/6/1/pubmed PY - 2001/3/28/medline PY - 1985/6/1/entrez SP - 540 EP - 3 JF - The Journal of rheumatology JO - J Rheumatol VL - 12 IS - 3 N2 - The antihyperuricemic properties of amflutizole were investigated in studies designed to determine its efficacy and mechanisms of action in individuals with gout and hyperuricemia. In a randomized double blind, multiple dose, crossover study of 29 patients, amflutizole caused a significant dose dependent reduction in serum urate concentrations. Mean serum urate concentrations decreased significantly from 9.6 +/- 1.5 mg/dl to 7.2 +/- 1.3 mg/dl with the 500 mg dosage (p less than 0.01). Detailed studies in 5 patients demonstrated evidence for modest xanthine oxidase inhibition. However, the majority of the antihyperuricemic effect was derived from an enhanced renal clearance of uric acid. Although the drug has significant antihyperuricemic properties, these were inadequate to achieve adequate control of the serum urate concentration in hyperuricemia and gout at the doses utilized. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/3900392/Antihyperuricemic_properties_of_amflutizole_in_gout_ DB - PRIME DP - Unbound Medicine ER -