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Perinatal galactose metabolism.
J Pediatr. 1985 Dec; 107(6):831-41.JPed

Abstract

Galactose is a major nutrient in normal newborn infants and serves as a substrate for energy production and fuel storage and a regulator of carbohydrate assimilation. Inborn errors of galactose metabolism have contributed to our understanding of the potential toxicity of this carbohydrate. In addition to the classic acute manifestations of neonatal galactosemia, long-term follow-up of surviving patients have revealed unusual neurodevelopmental and reproductive problems. Many investigators have suggested that the newborn infant can utilize galactose better than adults and that neonatal galactose assimilation exceeds that of glucose. Galactose may be an excellent substitute for glucose among hyperinsulinemic infants of diabetic mothers or premature infants with glucose intolerance. However, until further investigations are performed to define the role of galactose in newborn nutrition and to determine its potential toxicity, galactose should not be used as the primary carbohydrate in sick newborn infants.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

3906069

Citation

Kliegman, R M., and J W. Sparks. "Perinatal Galactose Metabolism." The Journal of Pediatrics, vol. 107, no. 6, 1985, pp. 831-41.
Kliegman RM, Sparks JW. Perinatal galactose metabolism. J Pediatr. 1985;107(6):831-41.
Kliegman, R. M., & Sparks, J. W. (1985). Perinatal galactose metabolism. The Journal of Pediatrics, 107(6), 831-41.
Kliegman RM, Sparks JW. Perinatal Galactose Metabolism. J Pediatr. 1985;107(6):831-41. PubMed PMID: 3906069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal galactose metabolism. AU - Kliegman,R M, AU - Sparks,J W, PY - 1985/12/1/pubmed PY - 1985/12/1/medline PY - 1985/12/1/entrez SP - 831 EP - 41 JF - The Journal of pediatrics JO - J Pediatr VL - 107 IS - 6 N2 - Galactose is a major nutrient in normal newborn infants and serves as a substrate for energy production and fuel storage and a regulator of carbohydrate assimilation. Inborn errors of galactose metabolism have contributed to our understanding of the potential toxicity of this carbohydrate. In addition to the classic acute manifestations of neonatal galactosemia, long-term follow-up of surviving patients have revealed unusual neurodevelopmental and reproductive problems. Many investigators have suggested that the newborn infant can utilize galactose better than adults and that neonatal galactose assimilation exceeds that of glucose. Galactose may be an excellent substitute for glucose among hyperinsulinemic infants of diabetic mothers or premature infants with glucose intolerance. However, until further investigations are performed to define the role of galactose in newborn nutrition and to determine its potential toxicity, galactose should not be used as the primary carbohydrate in sick newborn infants. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/3906069/Perinatal_galactose_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(85)80173-6 DB - PRIME DP - Unbound Medicine ER -