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An open trial of clotrimazole plus hydrocortisone cream in the treatment of napkin dermatitis in general practice.
Pharmatherapeutica. 1985; 4(5):314-8.P

Abstract

An open, non-comparative, multi-centre study was carried out in general practice to assess the effectiveness, acceptability and tolerability of a 1% clotrimazole plus 1% hydrocortisone cream in the treatment of 112 infants with napkin dermatitis. The cream was applied twice daily to the affected area for 7 days and treatment was extended to 14 days for those who failed to respond adequately. Assessments made of the severity of symptoms showed that there was significant improvement in erythema, irritation and pustulation in all but a few patients and an overall impression of clinical response made at the last patient visit indicated that 92% of the patients were considered to have been cured or markedly improved. Acceptability and tolerability were good. In 2 cases, parents reported adverse reactions of discomfort during application of the cream and in 1 of these cases treatment was withdrawn after 4 days.

Authors

Jaffé GV
No affiliation info available
Grimshaw JJ
No affiliation info available

MeSH

Clinical Trials as TopicClotrimazoleDiaper RashDrug CombinationsFemaleHumansHydrocortisoneImidazolesInfantMaleTime Factors

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

3906675

Citation

Jaffé, G V., and J J. Grimshaw. "An Open Trial of Clotrimazole Plus Hydrocortisone Cream in the Treatment of Napkin Dermatitis in General Practice." Pharmatherapeutica, vol. 4, no. 5, 1985, pp. 314-8.
Jaffé GV, Grimshaw JJ. An open trial of clotrimazole plus hydrocortisone cream in the treatment of napkin dermatitis in general practice. Pharmatherapeutica. 1985;4(5):314-8.
Jaffé, G. V., & Grimshaw, J. J. (1985). An open trial of clotrimazole plus hydrocortisone cream in the treatment of napkin dermatitis in general practice. Pharmatherapeutica, 4(5), 314-8.
Jaffé GV, Grimshaw JJ. An Open Trial of Clotrimazole Plus Hydrocortisone Cream in the Treatment of Napkin Dermatitis in General Practice. Pharmatherapeutica. 1985;4(5):314-8. PubMed PMID: 3906675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An open trial of clotrimazole plus hydrocortisone cream in the treatment of napkin dermatitis in general practice. AU - Jaffé,G V, AU - Grimshaw,J J, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 314 EP - 8 JF - Pharmatherapeutica JO - Pharmatherapeutica VL - 4 IS - 5 N2 - An open, non-comparative, multi-centre study was carried out in general practice to assess the effectiveness, acceptability and tolerability of a 1% clotrimazole plus 1% hydrocortisone cream in the treatment of 112 infants with napkin dermatitis. The cream was applied twice daily to the affected area for 7 days and treatment was extended to 14 days for those who failed to respond adequately. Assessments made of the severity of symptoms showed that there was significant improvement in erythema, irritation and pustulation in all but a few patients and an overall impression of clinical response made at the last patient visit indicated that 92% of the patients were considered to have been cured or markedly improved. Acceptability and tolerability were good. In 2 cases, parents reported adverse reactions of discomfort during application of the cream and in 1 of these cases treatment was withdrawn after 4 days. SN - 0308-051X UR - https://www.unboundmedicine.com/medline/citation/3906675/An_open_trial_of_clotrimazole_plus_hydrocortisone_cream_in_the_treatment_of_napkin_dermatitis_in_general_practice_ DB - PRIME DP - Unbound Medicine ER -