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[Malaria chemoprophylaxis. Resistance problems].
Arch Fr Pediatr. 1985 Dec; 42 Suppl 2:971-5.AF

Abstract

Several drugs are used for malaria chemoprophylaxis: 4 amino-quinolines, antifolics, combinations of sulfonamides and antifolics, and new anti-malarial agents, including mefloquine. The indications and contra-indications of their use are reviewed with respect to their tolerance and pharmacokinetics. Severe side effects associated with the administration of sulfonamide + pyrimethamine are discussed. The development of Plasmodium falciparum resistance to chloroquine and other agents creates a new challenge for chemoprophylaxis. The choice of chemoprophylaxis is dictated by the geographical incidence of resistance: in low risk areas (no chloroquine resistance), 4-amino-quinolines should be used because of the good tolerance; in medium risk areas (low frequency of resistant strains), amodiaquine is useful for prophylaxis and presumptive treatment of fevers is indicated; in high risk areas (high incidence of resistant strains), no anti-malarial agent but the newly developed mefloquine is effective.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

3914247

Citation

Danis, M, and M Gentilini. "[Malaria Chemoprophylaxis. Resistance Problems]." Archives Francaises De Pediatrie, vol. 42 Suppl 2, 1985, pp. 971-5.
Danis M, Gentilini M. [Malaria chemoprophylaxis. Resistance problems]. Arch Fr Pediatr. 1985;42 Suppl 2:971-5.
Danis, M., & Gentilini, M. (1985). [Malaria chemoprophylaxis. Resistance problems]. Archives Francaises De Pediatrie, 42 Suppl 2, 971-5.
Danis M, Gentilini M. [Malaria Chemoprophylaxis. Resistance Problems]. Arch Fr Pediatr. 1985;42 Suppl 2:971-5. PubMed PMID: 3914247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Malaria chemoprophylaxis. Resistance problems]. AU - Danis,M, AU - Gentilini,M, PY - 1985/12/1/pubmed PY - 1985/12/1/medline PY - 1985/12/1/entrez SP - 971 EP - 5 JF - Archives francaises de pediatrie JO - Arch Fr Pediatr VL - 42 Suppl 2 N2 - Several drugs are used for malaria chemoprophylaxis: 4 amino-quinolines, antifolics, combinations of sulfonamides and antifolics, and new anti-malarial agents, including mefloquine. The indications and contra-indications of their use are reviewed with respect to their tolerance and pharmacokinetics. Severe side effects associated with the administration of sulfonamide + pyrimethamine are discussed. The development of Plasmodium falciparum resistance to chloroquine and other agents creates a new challenge for chemoprophylaxis. The choice of chemoprophylaxis is dictated by the geographical incidence of resistance: in low risk areas (no chloroquine resistance), 4-amino-quinolines should be used because of the good tolerance; in medium risk areas (low frequency of resistant strains), amodiaquine is useful for prophylaxis and presumptive treatment of fevers is indicated; in high risk areas (high incidence of resistant strains), no anti-malarial agent but the newly developed mefloquine is effective. SN - 0003-9764 UR - https://www.unboundmedicine.com/medline/citation/3914247/[Malaria_chemoprophylaxis__Resistance_problems]_ L2 - https://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -