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Effect of repeated lepromin testing on experimental nine-banded armadillo leprosy.
Indian J Lepr. 1985 Oct-Dec; 57(4):716-27.IJ

Abstract

Twenty-eight armadillos were lepromin tested and infected with M. leprae; 18 intravenously and 10 intradermally. The lepromin test was repeated after 3 months and at intervals of 6 months thereafter until their death or sacrifice up to 30 months. The one animal with tuberculoid lepromin was resistant and 14 of the 16 with lepromatous lepromin developed generalized disease. Of the 11 with borderline lepromin, 6 developed disseminated disease and 5 were resistant. There is a definite relationship between resistance and tuberculoid lepromin in the armadillo. Repeated lepromin testing had no effect in the rate of infection and the course of the disease in animals infected intravenously. In the intradermally infected animals the results were inconclusive. Whereas all the 20 animals with disseminated disease showed lesions in the liver, spleen and lymph nodes, only 4 animals had sciatic nerve involvement. Peripheral nerve trunk is not necessarily the preferred site in the armadillo. Lung lesions were an important cause of death in lepromatous armadillos.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3915005

Citation

Job, C K., et al. "Effect of Repeated Lepromin Testing On Experimental Nine-banded Armadillo Leprosy." Indian Journal of Leprosy, vol. 57, no. 4, 1985, pp. 716-27.
Job CK, Sanchez RM, Hastings RC. Effect of repeated lepromin testing on experimental nine-banded armadillo leprosy. Indian J Lepr. 1985;57(4):716-27.
Job, C. K., Sanchez, R. M., & Hastings, R. C. (1985). Effect of repeated lepromin testing on experimental nine-banded armadillo leprosy. Indian Journal of Leprosy, 57(4), 716-27.
Job CK, Sanchez RM, Hastings RC. Effect of Repeated Lepromin Testing On Experimental Nine-banded Armadillo Leprosy. Indian J Lepr. 1985 Oct-Dec;57(4):716-27. PubMed PMID: 3915005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of repeated lepromin testing on experimental nine-banded armadillo leprosy. AU - Job,C K, AU - Sanchez,R M, AU - Hastings,R C, PY - 1985/10/1/pubmed PY - 1985/10/1/medline PY - 1985/10/1/entrez SP - 716 EP - 27 JF - Indian journal of leprosy JO - Indian J Lepr VL - 57 IS - 4 N2 - Twenty-eight armadillos were lepromin tested and infected with M. leprae; 18 intravenously and 10 intradermally. The lepromin test was repeated after 3 months and at intervals of 6 months thereafter until their death or sacrifice up to 30 months. The one animal with tuberculoid lepromin was resistant and 14 of the 16 with lepromatous lepromin developed generalized disease. Of the 11 with borderline lepromin, 6 developed disseminated disease and 5 were resistant. There is a definite relationship between resistance and tuberculoid lepromin in the armadillo. Repeated lepromin testing had no effect in the rate of infection and the course of the disease in animals infected intravenously. In the intradermally infected animals the results were inconclusive. Whereas all the 20 animals with disseminated disease showed lesions in the liver, spleen and lymph nodes, only 4 animals had sciatic nerve involvement. Peripheral nerve trunk is not necessarily the preferred site in the armadillo. Lung lesions were an important cause of death in lepromatous armadillos. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/3915005/Effect_of_repeated_lepromin_testing_on_experimental_nine_banded_armadillo_leprosy_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -