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Concentration and uptake of 5-hydroxytryptamine in platelets from cluster headache and migraine patients.
Cephalalgia. 1985 Mar; 5(1):45-54.C

Abstract

Concentrations of 5-hydroxytryptamine (5-HT) in platelets were determined in 33 cluster headache patients (17 males) and in 34 migraine patients (16 males) outside attacks. The 5-HT uptake into platelets was measured and the kinetic constants Vmax and Km determined in 26 cluster patients (14 males) and in 30 migraine patients (13 males). Significantly lower 5-HT concentrations in whole blood were found in cluster headache and migraine patients than in 50 healthy controls (19 males). The Vmax and Km values of the 5-HT uptake were significantly lower in cluster headache and migraine patients compared with 22 healthy controls (9 males). The 5-HT concentrations and the kinetics of the 5-HT uptake did not differ between cluster headache and migraine. In healthy controls a significant positive correlation was found between the 5-HT uptake rate at 0.25 microM and Km but not in cluster headache and migraine patients. The 5-HT concentrations in whole blood correlated positively with Vmax and Km, respectively, in cluster headache and with Km in healthy controls but not with Vmax nor with Km in migraine. There was no obvious relation between the kinetics of platelet monoamine oxidase (MAO) and the 5-HT uptake except for an increased incidence of low Vmax of MAO and low Km of the 5-HT uptake in cluster headache. The kinetics of the 5-HT uptake was apparently not related to the state of migraine. The results indicate a possible constitutional trait in cluster headache and migraine expressed as low 5-HT concentrations in whole blood and low Vmax and Km of the 5-HT uptake into platelets.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3921257

Citation

Waldenlind, E, et al. "Concentration and Uptake of 5-hydroxytryptamine in Platelets From Cluster Headache and Migraine Patients." Cephalalgia : an International Journal of Headache, vol. 5, no. 1, 1985, pp. 45-54.
Waldenlind E, Ross SB, Sääf J, et al. Concentration and uptake of 5-hydroxytryptamine in platelets from cluster headache and migraine patients. Cephalalgia. 1985;5(1):45-54.
Waldenlind, E., Ross, S. B., Sääf, J., Ekbom, K., & Wetterberg, L. (1985). Concentration and uptake of 5-hydroxytryptamine in platelets from cluster headache and migraine patients. Cephalalgia : an International Journal of Headache, 5(1), 45-54.
Waldenlind E, et al. Concentration and Uptake of 5-hydroxytryptamine in Platelets From Cluster Headache and Migraine Patients. Cephalalgia. 1985;5(1):45-54. PubMed PMID: 3921257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concentration and uptake of 5-hydroxytryptamine in platelets from cluster headache and migraine patients. AU - Waldenlind,E, AU - Ross,S B, AU - Sääf,J, AU - Ekbom,K, AU - Wetterberg,L, PY - 1985/3/1/pubmed PY - 1985/3/1/medline PY - 1985/3/1/entrez SP - 45 EP - 54 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 5 IS - 1 N2 - Concentrations of 5-hydroxytryptamine (5-HT) in platelets were determined in 33 cluster headache patients (17 males) and in 34 migraine patients (16 males) outside attacks. The 5-HT uptake into platelets was measured and the kinetic constants Vmax and Km determined in 26 cluster patients (14 males) and in 30 migraine patients (13 males). Significantly lower 5-HT concentrations in whole blood were found in cluster headache and migraine patients than in 50 healthy controls (19 males). The Vmax and Km values of the 5-HT uptake were significantly lower in cluster headache and migraine patients compared with 22 healthy controls (9 males). The 5-HT concentrations and the kinetics of the 5-HT uptake did not differ between cluster headache and migraine. In healthy controls a significant positive correlation was found between the 5-HT uptake rate at 0.25 microM and Km but not in cluster headache and migraine patients. The 5-HT concentrations in whole blood correlated positively with Vmax and Km, respectively, in cluster headache and with Km in healthy controls but not with Vmax nor with Km in migraine. There was no obvious relation between the kinetics of platelet monoamine oxidase (MAO) and the 5-HT uptake except for an increased incidence of low Vmax of MAO and low Km of the 5-HT uptake in cluster headache. The kinetics of the 5-HT uptake was apparently not related to the state of migraine. The results indicate a possible constitutional trait in cluster headache and migraine expressed as low 5-HT concentrations in whole blood and low Vmax and Km of the 5-HT uptake into platelets. SN - 0333-1024 UR - https://www.unboundmedicine.com/medline/citation/3921257/Concentration_and_uptake_of_5_hydroxytryptamine_in_platelets_from_cluster_headache_and_migraine_patients_ L2 - https://journals.sagepub.com/doi/10.1046/j.1468-2982.1985.0501045.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -