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Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis.
FEBS Lett. 1985 Jun 03; 185(1):139-41.FL

Abstract

The complete amino acid sequence of an amyloidogenic Bence Jones protein (NIG-84) from an individual with myeloma-associated systemic amyloidosis has been determined. The protein, with a blocked N-terminus, represents a complete light chain consisting of 217 residues and it has a structural feature characteristic of the V lambda II subgroup. In addition to a two-residue insertion at positions 28 and 29, it has an additional rare insertion of alanine at position 100. NIG-84 is an example of the first complete sequence presented for the amyloidogenic Bence Jones protein of the V lambda II subgroup.

Authors

Tonoike H
No affiliation info available
Kametani F
No affiliation info available
Hoshi A
No affiliation info available
Shinoda T
No affiliation info available
Isobe T
No affiliation info available

MeSH

Amino Acid SequenceAmyloidosisBence Jones ProteinHumansImmunoglobulin Constant RegionsImmunoglobulin Variable RegionImmunoglobulin lambda-ChainsMultiple Myeloma

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3922791

Citation

Tonoike, H, et al. "Amino Acid Sequence of an Amyloidogenic Bence Jones Protein in Myeloma-associated Systemic Amyloidosis." FEBS Letters, vol. 185, no. 1, 1985, pp. 139-41.
Tonoike H, Kametani F, Hoshi A, et al. Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis. FEBS Lett. 1985;185(1):139-41.
Tonoike, H., Kametani, F., Hoshi, A., Shinoda, T., & Isobe, T. (1985). Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis. FEBS Letters, 185(1), 139-41.
Tonoike H, et al. Amino Acid Sequence of an Amyloidogenic Bence Jones Protein in Myeloma-associated Systemic Amyloidosis. FEBS Lett. 1985 Jun 3;185(1):139-41. PubMed PMID: 3922791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis. AU - Tonoike,H, AU - Kametani,F, AU - Hoshi,A, AU - Shinoda,T, AU - Isobe,T, PY - 1985/6/3/pubmed PY - 1985/6/3/medline PY - 1985/6/3/entrez SP - 139 EP - 41 JF - FEBS letters JO - FEBS Lett VL - 185 IS - 1 N2 - The complete amino acid sequence of an amyloidogenic Bence Jones protein (NIG-84) from an individual with myeloma-associated systemic amyloidosis has been determined. The protein, with a blocked N-terminus, represents a complete light chain consisting of 217 residues and it has a structural feature characteristic of the V lambda II subgroup. In addition to a two-residue insertion at positions 28 and 29, it has an additional rare insertion of alanine at position 100. NIG-84 is an example of the first complete sequence presented for the amyloidogenic Bence Jones protein of the V lambda II subgroup. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/3922791/Amino_acid_sequence_of_an_amyloidogenic_Bence_Jones_protein_in_myeloma_associated_systemic_amyloidosis_ DB - PRIME DP - Unbound Medicine ER -