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Human lambda light-chain constant region gene CMor lambda: the primary structure of lambda VI Bence Jones protein Mor.
Proc Natl Acad Sci U S A. 1985 May; 82(10):3415-9.PN

Abstract

Serologic, structural, and genetic analyses have shown that the constant (C) region of human kappa light chains is encoded by a single gene, whereas that of lambda chains is encoded by multiple genes. We have determined the complete C region amino acid sequence of two monoclonal lambda VI light chains, Bence Jones proteins Sut and Mor. The C region of lambda chains Sut and Mor consists of 105 residues, as is characteristic for human lambda light chains, of which 102 are identical in sequence. Protein Sut has the C region sequence associated with the C lambda isotype Mcg-, Kern-, Oz+ and represents a product of the C lambda 3 (Kern-, Oz+) gene. Protein Mor has a C region sequence associated with Mcg-, Kern-, and Oz- proteins but differs from protein Sut by the presence of three amino acid interchanges at positions 168, 176, and 194. These substitutions distinguish protein Mor from lambda chains encoded by the C lambda 1 (Mcg+), C lambda 2 (Kern-, Oz-), and C lambda 3 (Kern-, Oz+) genes and provide further evidence for polymorphism of the human C lambda genome. The gene encoding the C region sequence of lambda chain Mor is designated CMor lambda.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3923477

Citation

Frangione, B, et al. "Human Lambda Light-chain Constant Region Gene CMor Lambda: the Primary Structure of Lambda VI Bence Jones Protein Mor." Proceedings of the National Academy of Sciences of the United States of America, vol. 82, no. 10, 1985, pp. 3415-9.
Frangione B, Moloshok T, Prelli F, et al. Human lambda light-chain constant region gene CMor lambda: the primary structure of lambda VI Bence Jones protein Mor. Proc Natl Acad Sci U S A. 1985;82(10):3415-9.
Frangione, B., Moloshok, T., Prelli, F., & Solomon, A. (1985). Human lambda light-chain constant region gene CMor lambda: the primary structure of lambda VI Bence Jones protein Mor. Proceedings of the National Academy of Sciences of the United States of America, 82(10), 3415-9.
Frangione B, et al. Human Lambda Light-chain Constant Region Gene CMor Lambda: the Primary Structure of Lambda VI Bence Jones Protein Mor. Proc Natl Acad Sci U S A. 1985;82(10):3415-9. PubMed PMID: 3923477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human lambda light-chain constant region gene CMor lambda: the primary structure of lambda VI Bence Jones protein Mor. AU - Frangione,B, AU - Moloshok,T, AU - Prelli,F, AU - Solomon,A, PY - 1985/5/1/pubmed PY - 1985/5/1/medline PY - 1985/5/1/entrez SP - 3415 EP - 9 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 82 IS - 10 N2 - Serologic, structural, and genetic analyses have shown that the constant (C) region of human kappa light chains is encoded by a single gene, whereas that of lambda chains is encoded by multiple genes. We have determined the complete C region amino acid sequence of two monoclonal lambda VI light chains, Bence Jones proteins Sut and Mor. The C region of lambda chains Sut and Mor consists of 105 residues, as is characteristic for human lambda light chains, of which 102 are identical in sequence. Protein Sut has the C region sequence associated with the C lambda isotype Mcg-, Kern-, Oz+ and represents a product of the C lambda 3 (Kern-, Oz+) gene. Protein Mor has a C region sequence associated with Mcg-, Kern-, and Oz- proteins but differs from protein Sut by the presence of three amino acid interchanges at positions 168, 176, and 194. These substitutions distinguish protein Mor from lambda chains encoded by the C lambda 1 (Mcg+), C lambda 2 (Kern-, Oz-), and C lambda 3 (Kern-, Oz+) genes and provide further evidence for polymorphism of the human C lambda genome. The gene encoding the C region sequence of lambda chain Mor is designated CMor lambda. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/3923477/Human_lambda_light_chain_constant_region_gene_CMor_lambda:_the_primary_structure_of_lambda_VI_Bence_Jones_protein_Mor_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=3923477 DB - PRIME DP - Unbound Medicine ER -