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Enlargement of Lyt-2-positive T cells is associated with functional impairment and autoimmune hemolytic anemia in New Zealand Black mice.
J Immunol. 1985 Oct; 135(4):2432-7.JI

Abstract

We investigated the relationship between the increased cell diameter of Lyt-2+ T cells and the development of autoimmune disease in aging NZB and NZB X NZW F1 hybrid (BW) mice. Individual animals were analyzed for Lyt-2+ T cell size (by narrow-angle forward light scatter), anti-erythrocyte autoantibodies, anemia, proteinuria, and splenomegaly. The peak light scatter of the Lyt-2+ T cells correlated with the level of anti-erythrocyte autoantibodies and severity of hemolytic anemia, but not with proteinuria or splenomegaly. The cell size of this T cell subset did not increase in old BW or in NZB mice homozygous for the xid gene (NZB.xid). The in vivo administration of bacterial lipopolysaccharide to young NZB mice did not stimulate the enlargement of Lyt-2+ T cells. Ly-2+ T cells from old NZB mice could be stimulated by concanavalin A (Con A) to express interleukin 2 (IL 2) receptors and to synthesize DNA in vitro. However, in vivo administration of Con A to old NZB mice did not induce the expression of IL 2 receptors on Lyt-2+ T cells. Further, in vivo T suppressor function was impaired in old NZB mice with enlarged Lyt-2+ T cells. Thus, the enlargement of Lyt-2+ T cells in old NZB mice appears related to impaired T cell function in vivo and is associated with the development of anti-erythrocyte autoantibodies and autoimmune hemolytic anemia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3928748

Citation

McCoy, K L., et al. "Enlargement of Lyt-2-positive T Cells Is Associated With Functional Impairment and Autoimmune Hemolytic Anemia in New Zealand Black Mice." Journal of Immunology (Baltimore, Md. : 1950), vol. 135, no. 4, 1985, pp. 2432-7.
McCoy KL, Baker PJ, Malek TR, et al. Enlargement of Lyt-2-positive T cells is associated with functional impairment and autoimmune hemolytic anemia in New Zealand Black mice. J Immunol. 1985;135(4):2432-7.
McCoy, K. L., Baker, P. J., Malek, T. R., & Chused, T. M. (1985). Enlargement of Lyt-2-positive T cells is associated with functional impairment and autoimmune hemolytic anemia in New Zealand Black mice. Journal of Immunology (Baltimore, Md. : 1950), 135(4), 2432-7.
McCoy KL, et al. Enlargement of Lyt-2-positive T Cells Is Associated With Functional Impairment and Autoimmune Hemolytic Anemia in New Zealand Black Mice. J Immunol. 1985;135(4):2432-7. PubMed PMID: 3928748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enlargement of Lyt-2-positive T cells is associated with functional impairment and autoimmune hemolytic anemia in New Zealand Black mice. AU - McCoy,K L, AU - Baker,P J, AU - Malek,T R, AU - Chused,T M, PY - 1985/10/1/pubmed PY - 1985/10/1/medline PY - 1985/10/1/entrez SP - 2432 EP - 7 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 135 IS - 4 N2 - We investigated the relationship between the increased cell diameter of Lyt-2+ T cells and the development of autoimmune disease in aging NZB and NZB X NZW F1 hybrid (BW) mice. Individual animals were analyzed for Lyt-2+ T cell size (by narrow-angle forward light scatter), anti-erythrocyte autoantibodies, anemia, proteinuria, and splenomegaly. The peak light scatter of the Lyt-2+ T cells correlated with the level of anti-erythrocyte autoantibodies and severity of hemolytic anemia, but not with proteinuria or splenomegaly. The cell size of this T cell subset did not increase in old BW or in NZB mice homozygous for the xid gene (NZB.xid). The in vivo administration of bacterial lipopolysaccharide to young NZB mice did not stimulate the enlargement of Lyt-2+ T cells. Ly-2+ T cells from old NZB mice could be stimulated by concanavalin A (Con A) to express interleukin 2 (IL 2) receptors and to synthesize DNA in vitro. However, in vivo administration of Con A to old NZB mice did not induce the expression of IL 2 receptors on Lyt-2+ T cells. Further, in vivo T suppressor function was impaired in old NZB mice with enlarged Lyt-2+ T cells. Thus, the enlargement of Lyt-2+ T cells in old NZB mice appears related to impaired T cell function in vivo and is associated with the development of anti-erythrocyte autoantibodies and autoimmune hemolytic anemia. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/3928748/Enlargement_of_Lyt_2_positive_T_cells_is_associated_with_functional_impairment_and_autoimmune_hemolytic_anemia_in_New_Zealand_Black_mice_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=3928748 DB - PRIME DP - Unbound Medicine ER -