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Efficacy of feverfew as prophylactic treatment of migraine.
Br Med J (Clin Res Ed) 1985; 291(6495):569-73BM

Abstract

Seventeen patients who ate fresh leaves of feverfew daily as prophylaxis against migraine participated in a double blind placebo controlled trial of the herb: eight patients received capsules containing freeze dried feverfew powder and nine placebo. Those who received placebo had a significant increase in the frequency and severity of headache, nausea, and vomiting with the emergence of untoward effects during the early months of treatment. The group given capsules of feverfew showed no change in the frequency or severity of symptoms of migraine. This provides evidence that feverfew taken prophylactically prevents attacks of migraine, and confirmatory studies are now indicated, preferably with a formulation controlled for sesquiterpene lactone content, in migraine sufferers who have never treated themselves with this herb.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3929876

Citation

Johnson, E S., et al. "Efficacy of Feverfew as Prophylactic Treatment of Migraine." British Medical Journal (Clinical Research Ed.), vol. 291, no. 6495, 1985, pp. 569-73.
Johnson ES, Kadam NP, Hylands DM, et al. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed). 1985;291(6495):569-73.
Johnson, E. S., Kadam, N. P., Hylands, D. M., & Hylands, P. J. (1985). Efficacy of feverfew as prophylactic treatment of migraine. British Medical Journal (Clinical Research Ed.), 291(6495), pp. 569-73.
Johnson ES, et al. Efficacy of Feverfew as Prophylactic Treatment of Migraine. Br Med J (Clin Res Ed). 1985 Aug 31;291(6495):569-73. PubMed PMID: 3929876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of feverfew as prophylactic treatment of migraine. AU - Johnson,E S, AU - Kadam,N P, AU - Hylands,D M, AU - Hylands,P J, PY - 1985/8/31/pubmed PY - 1985/8/31/medline PY - 1985/8/31/entrez SP - 569 EP - 73 JF - British medical journal (Clinical research ed.) JO - Br Med J (Clin Res Ed) VL - 291 IS - 6495 N2 - Seventeen patients who ate fresh leaves of feverfew daily as prophylaxis against migraine participated in a double blind placebo controlled trial of the herb: eight patients received capsules containing freeze dried feverfew powder and nine placebo. Those who received placebo had a significant increase in the frequency and severity of headache, nausea, and vomiting with the emergence of untoward effects during the early months of treatment. The group given capsules of feverfew showed no change in the frequency or severity of symptoms of migraine. This provides evidence that feverfew taken prophylactically prevents attacks of migraine, and confirmatory studies are now indicated, preferably with a formulation controlled for sesquiterpene lactone content, in migraine sufferers who have never treated themselves with this herb. SN - 0267-0623 UR - https://www.unboundmedicine.com/medline/citation/3929876/Efficacy_of_feverfew_as_prophylactic_treatment_of_migraine_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3929876/ DB - PRIME DP - Unbound Medicine ER -