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Lymphocyte function in recurrent aphthous ulceration.
J Oral Pathol. 1985 Sep; 14(8):592-602.JO

Abstract

Lymphocyte blast transformation responses to mitogens and to streptococcal, adenovirus Type 1, and oral mucosal antigens were studied in 32 patients with recurrent aphthous ulceration (RAU) and matched control subjects. RAU patients showed significantly depressed (p less than 0.05) responses to mitogens in comparison with matched controls, but there was no significant difference between patients and controls in response to any of the antigens tested. These results indicate that neither cell-mediated hypersensitivity to streptococcal or viral antigens nor cross-reactivity between oral mucosal and streptococcal antigens are likely to play a role in the pathogenesis of RAU. Rather, the data support the hypothesis of an imbalance or defect in immune cell subpopulations.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3930669

Citation

Greenspan, J S., et al. "Lymphocyte Function in Recurrent Aphthous Ulceration." Journal of Oral Pathology, vol. 14, no. 8, 1985, pp. 592-602.
Greenspan JS, Gadol N, Olson JA, et al. Lymphocyte function in recurrent aphthous ulceration. J Oral Pathol. 1985;14(8):592-602.
Greenspan, J. S., Gadol, N., Olson, J. A., Hoover, C. I., Jacobsen, P. L., Shillitoe, E. J., & Armitage, G. C. (1985). Lymphocyte function in recurrent aphthous ulceration. Journal of Oral Pathology, 14(8), 592-602.
Greenspan JS, et al. Lymphocyte Function in Recurrent Aphthous Ulceration. J Oral Pathol. 1985;14(8):592-602. PubMed PMID: 3930669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphocyte function in recurrent aphthous ulceration. AU - Greenspan,J S, AU - Gadol,N, AU - Olson,J A, AU - Hoover,C I, AU - Jacobsen,P L, AU - Shillitoe,E J, AU - Armitage,G C, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 592 EP - 602 JF - Journal of oral pathology JO - J Oral Pathol VL - 14 IS - 8 N2 - Lymphocyte blast transformation responses to mitogens and to streptococcal, adenovirus Type 1, and oral mucosal antigens were studied in 32 patients with recurrent aphthous ulceration (RAU) and matched control subjects. RAU patients showed significantly depressed (p less than 0.05) responses to mitogens in comparison with matched controls, but there was no significant difference between patients and controls in response to any of the antigens tested. These results indicate that neither cell-mediated hypersensitivity to streptococcal or viral antigens nor cross-reactivity between oral mucosal and streptococcal antigens are likely to play a role in the pathogenesis of RAU. Rather, the data support the hypothesis of an imbalance or defect in immune cell subpopulations. SN - 0300-9777 UR - https://www.unboundmedicine.com/medline/citation/3930669/Lymphocyte_function_in_recurrent_aphthous_ulceration_ L2 - https://medlineplus.gov/cankersores.html DB - PRIME DP - Unbound Medicine ER -