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[Arginine-GnRH-TRH test in patients with primary hypothalamic amenorrhea].
Zentralbl Gynakol. 1985; 107(16):996-1002.ZG

Abstract

In 8 patients with hypothalamic primary amenorrhea aged from 16 to 23 years (average age 19,4 years) a sequential stimulations test was performed with 0,5 g arginine hydrochloride per kg body weight, 25 micrograms gonadotropin-releasing hormone (GnRH) and 200 micrograms thyreotropin-releasing hormone (TRH). The response of the lactotropic, gonadotropic, thyreotropic and somatotropic cells of the pituitary was investigated. Serum levels of PRL, LH, FSH, TSH and HGH were determined by RIA. In all women hypoplastic ovaries were found by laparoscopy. In 7 patients tissue biopsies showed primordial follicles or primordial and secondary follicles, respectively. Investigations point to, that in hypothalamic primary amenorrhea at first the function of the gonadotropic and lactotropic cells of the pituitary is injured. The somatotropic cells could not be stimulated in 3 of 8 patients, the function of hypothalamo-pituitary-thyroid-axis in the stimulations test was normal in all women.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

3931389

Citation

Rudolf, K, et al. "[Arginine-GnRH-TRH Test in Patients With Primary Hypothalamic Amenorrhea]." Zentralblatt Fur Gynakologie, vol. 107, no. 16, 1985, pp. 996-1002.
Rudolf K, Kunkel S, Sudik R, et al. [Arginine-GnRH-TRH test in patients with primary hypothalamic amenorrhea]. Zentralbl Gynakol. 1985;107(16):996-1002.
Rudolf, K., Kunkel, S., Sudik, R., Rüting, M., & Rohde, E. (1985). [Arginine-GnRH-TRH test in patients with primary hypothalamic amenorrhea]. Zentralblatt Fur Gynakologie, 107(16), 996-1002.
Rudolf K, et al. [Arginine-GnRH-TRH Test in Patients With Primary Hypothalamic Amenorrhea]. Zentralbl Gynakol. 1985;107(16):996-1002. PubMed PMID: 3931389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Arginine-GnRH-TRH test in patients with primary hypothalamic amenorrhea]. AU - Rudolf,K, AU - Kunkel,S, AU - Sudik,R, AU - Rüting,M, AU - Rohde,E, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 996 EP - 1002 JF - Zentralblatt fur Gynakologie JO - Zentralbl Gynakol VL - 107 IS - 16 N2 - In 8 patients with hypothalamic primary amenorrhea aged from 16 to 23 years (average age 19,4 years) a sequential stimulations test was performed with 0,5 g arginine hydrochloride per kg body weight, 25 micrograms gonadotropin-releasing hormone (GnRH) and 200 micrograms thyreotropin-releasing hormone (TRH). The response of the lactotropic, gonadotropic, thyreotropic and somatotropic cells of the pituitary was investigated. Serum levels of PRL, LH, FSH, TSH and HGH were determined by RIA. In all women hypoplastic ovaries were found by laparoscopy. In 7 patients tissue biopsies showed primordial follicles or primordial and secondary follicles, respectively. Investigations point to, that in hypothalamic primary amenorrhea at first the function of the gonadotropic and lactotropic cells of the pituitary is injured. The somatotropic cells could not be stimulated in 3 of 8 patients, the function of hypothalamo-pituitary-thyroid-axis in the stimulations test was normal in all women. SN - 0044-4197 UR - https://www.unboundmedicine.com/medline/citation/3931389/[Arginine_GnRH_TRH_test_in_patients_with_primary_hypothalamic_amenorrhea]_ DB - PRIME DP - Unbound Medicine ER -