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Effect of low-dose dopamine infusion on basal and stimulated TSH and prolactin concentrations in man.
Clin Endocrinol (Oxf). 1985 Aug; 23(2):185-92.CE

Abstract

Dopamine (DA) infused at pharmacological doses in man inhibits thyrotrophin (TSH) secretion, although the physiological significance of this observation is unclear. The effect of low-dose DA infusion (0.1 microgram/kg/min) on TSH and prolactin (PRL) concentrations during stimulation with thyrotrophin releasing hormone (TRH) in normal male subjects is reported. Six subjects were given intravenous DA or placebo infusions for 165 min on separate days. A bolus of TRH (7.5 micrograms) was given at + 90 min, followed by infusion of the tripeptide (750 ng/min) for 45 min during both DA and placebo studies. In all subjects TRH administration caused a small rise in TSH which was partially inhibited by DA (peak 5.73 +/- 0.85 mU/l vs 4.58 +/- 1.09, P less than 0.05). PRL response to TRH was almost totally inhibited by DA (620 +/- 164 mU/l vs 234 +/- 96, P less than 0.05); integrated TSH and PRL responses to TRH were similarly inhibited by DA. Circulating plasma DA concentration during infusion of the catecholamine was 3.46 +/- 1.00 ng/ml, which is within the range reported in pituitary stalk plasma of other species. These data support the hypothesis that DA is a physiological modulator of TSH secretion in normal man. Major differences in the time course of TSH and PRL responses to TRH, and in the suppressive effect of DA on these responses suggest that there are fundamental differences in stimulus-secretion coupling for TRH and the lactotroph and thyrotroph.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3931943

Citation

Connell, J M., et al. "Effect of Low-dose Dopamine Infusion On Basal and Stimulated TSH and Prolactin Concentrations in Man." Clinical Endocrinology, vol. 23, no. 2, 1985, pp. 185-92.
Connell JM, Ball SG, Balmforth AJ, et al. Effect of low-dose dopamine infusion on basal and stimulated TSH and prolactin concentrations in man. Clin Endocrinol (Oxf). 1985;23(2):185-92.
Connell, J. M., Ball, S. G., Balmforth, A. J., Beastall, G. H., & Davies, D. L. (1985). Effect of low-dose dopamine infusion on basal and stimulated TSH and prolactin concentrations in man. Clinical Endocrinology, 23(2), 185-92.
Connell JM, et al. Effect of Low-dose Dopamine Infusion On Basal and Stimulated TSH and Prolactin Concentrations in Man. Clin Endocrinol (Oxf). 1985;23(2):185-92. PubMed PMID: 3931943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of low-dose dopamine infusion on basal and stimulated TSH and prolactin concentrations in man. AU - Connell,J M, AU - Ball,S G, AU - Balmforth,A J, AU - Beastall,G H, AU - Davies,D L, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 185 EP - 92 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 23 IS - 2 N2 - Dopamine (DA) infused at pharmacological doses in man inhibits thyrotrophin (TSH) secretion, although the physiological significance of this observation is unclear. The effect of low-dose DA infusion (0.1 microgram/kg/min) on TSH and prolactin (PRL) concentrations during stimulation with thyrotrophin releasing hormone (TRH) in normal male subjects is reported. Six subjects were given intravenous DA or placebo infusions for 165 min on separate days. A bolus of TRH (7.5 micrograms) was given at + 90 min, followed by infusion of the tripeptide (750 ng/min) for 45 min during both DA and placebo studies. In all subjects TRH administration caused a small rise in TSH which was partially inhibited by DA (peak 5.73 +/- 0.85 mU/l vs 4.58 +/- 1.09, P less than 0.05). PRL response to TRH was almost totally inhibited by DA (620 +/- 164 mU/l vs 234 +/- 96, P less than 0.05); integrated TSH and PRL responses to TRH were similarly inhibited by DA. Circulating plasma DA concentration during infusion of the catecholamine was 3.46 +/- 1.00 ng/ml, which is within the range reported in pituitary stalk plasma of other species. These data support the hypothesis that DA is a physiological modulator of TSH secretion in normal man. Major differences in the time course of TSH and PRL responses to TRH, and in the suppressive effect of DA on these responses suggest that there are fundamental differences in stimulus-secretion coupling for TRH and the lactotroph and thyrotroph. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/3931943/Effect_of_low_dose_dopamine_infusion_on_basal_and_stimulated_TSH_and_prolactin_concentrations_in_man_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1985&volume=23&issue=2&spage=185 DB - PRIME DP - Unbound Medicine ER -