TY - JOUR T1 - A comparative study of methyldopa and labetalol in the treatment of hypertension. AU - Sanders,G L, AU - Davies,D M, AU - Gales,G M, AU - Rao,J G, AU - Rawlins,M D, AU - Routledge,P A, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 149S EP - 151S JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 8 IS - Suppl 2 N2 - 1 Twenty patients with essential hypertension completed a double-blind, dose-tritrated, cross-over comparison of methyldopa and labetalol. 2 Average lying BPs (systolic/diastolic) were reduced by 28/15 mmHg with methyldopa and by 23/15 mmHg with labetalol. 3 Average standing BPs (systolic/diastolic) were reduced by 29/14 mmHg with methyldopa and by 29/15 mmHg with labetalol. 4 Both lying and standing heart rates were reduced with labetalol. 5 It is concluded that the antihypertensive properties of labetalol and methyldopa are similar but that larger patient populations are needed to study the relative incidence of subjective adverse effects. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/393286/A_comparative_study_of_methyldopa_and_labetalol_in_the_treatment_of_hypertension_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1979&volume=8&issue=Suppl 2&spage=149S DB - PRIME DP - Unbound Medicine ER -