Tags

Type your tag names separated by a space and hit enter

Further observations on the role of IgE-mediated hypersensitivity in recurrent otitis media with effusion.
Otolaryngol Head Neck Surg. 1985 Oct; 93(5):611-5.OH

Abstract

One hundred young patients with recurrent otitis media with effusion (OME) were evaluated for IgE-mediated hypersensitivity by critical analysis of history, physical findings, skin testing for selected antigen, laboratory determination of total IgE, and radioallergosorbent testing (RAST) for six inhalant and two food allergens. The patients could be divided into allergic rhinitis and nonallergic groups. Allergic rhinitis patients had higher total IgE in their serum, and middle ear effusion (MEE). IgE was elevated in 16 of 35 allergic patients. In 8 of these 16 (23% of the allergic group), the IgE/mg protein was higher in the MEE than in the corresponding serum, suggesting local production of IgE. Nasal IgE was substantially increased in the allergic patients; however, in many patients there was no correlation between the corresponding MEE IgE and elevated nasal IgE, suggesting that local production of nasal and middle ear IgE is independent. We conclude that IgE-mediated allergic reactions may play a role in the pathogenesis of OME in about 23% of young allergic patients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3932928

Citation

Bernstein, J M., et al. "Further Observations On the Role of IgE-mediated Hypersensitivity in Recurrent Otitis Media With Effusion." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 93, no. 5, 1985, pp. 611-5.
Bernstein JM, Lee J, Conboy K, et al. Further observations on the role of IgE-mediated hypersensitivity in recurrent otitis media with effusion. Otolaryngol Head Neck Surg. 1985;93(5):611-5.
Bernstein, J. M., Lee, J., Conboy, K., Ellis, E., & Li, P. (1985). Further observations on the role of IgE-mediated hypersensitivity in recurrent otitis media with effusion. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 93(5), 611-5.
Bernstein JM, et al. Further Observations On the Role of IgE-mediated Hypersensitivity in Recurrent Otitis Media With Effusion. Otolaryngol Head Neck Surg. 1985;93(5):611-5. PubMed PMID: 3932928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further observations on the role of IgE-mediated hypersensitivity in recurrent otitis media with effusion. AU - Bernstein,J M, AU - Lee,J, AU - Conboy,K, AU - Ellis,E, AU - Li,P, PY - 1985/10/1/pubmed PY - 1985/10/1/medline PY - 1985/10/1/entrez SP - 611 EP - 5 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 93 IS - 5 N2 - One hundred young patients with recurrent otitis media with effusion (OME) were evaluated for IgE-mediated hypersensitivity by critical analysis of history, physical findings, skin testing for selected antigen, laboratory determination of total IgE, and radioallergosorbent testing (RAST) for six inhalant and two food allergens. The patients could be divided into allergic rhinitis and nonallergic groups. Allergic rhinitis patients had higher total IgE in their serum, and middle ear effusion (MEE). IgE was elevated in 16 of 35 allergic patients. In 8 of these 16 (23% of the allergic group), the IgE/mg protein was higher in the MEE than in the corresponding serum, suggesting local production of IgE. Nasal IgE was substantially increased in the allergic patients; however, in many patients there was no correlation between the corresponding MEE IgE and elevated nasal IgE, suggesting that local production of nasal and middle ear IgE is independent. We conclude that IgE-mediated allergic reactions may play a role in the pathogenesis of OME in about 23% of young allergic patients. SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/3932928/Further_observations_on_the_role_of_IgE_mediated_hypersensitivity_in_recurrent_otitis_media_with_effusion_ L2 - https://journals.sagepub.com/doi/10.1177/019459988509300508?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -