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Thyroid-stimulating hormone, prolactin, and growth hormone response to thyrotropin-releasing hormone in treated children with congenital hypothyroidism.
Pediatr Res. 1985 Oct; 19(10):1037-9.PR

Abstract

The purpose of the present study was to assess thyroid-stimulating hormone (TSH), prolactin, and growth hormone responses to TRH stimulation in 12 congenitally hypothyroid children adequately treated with L-thyroxine from the first weeks of life. Although clinically euthyroid, six of these children were found to have abnormally high basal serum TSH concentrations despite clinical euthyroidism. Serum triiodothyroxine and L-thyroxine concentrations were normal and did not differ whether the children had elevated or normal basal serum TSH. All six of the children with high basal TSH had an exaggerated TSH response to TRH and 4 of them also had an augmented prolactin response to TRH. The children with normal basal TSH concentrations had normal TSH and prolactin responses to TRH. An abnormal ("paradoxical") elevation of growth hormone concentration in response to TRH was found in four of seven children in a separate group of patients who had prolonged, untreated primary hypothyroidism, but such responses were not found in any of the adequately treated children. These findings suggest the following conclusions: 1) the phenomenon of high serum concentrations of TSH in conjunction with normal L-thyroxine and triiodothyronine levels (and clinical euthyroidism), is prevalent in congenital hypothyroid patients. 2) These patients have an exaggerated response of their pituitary thyrotroph and lactotroph cells to TRH, presumably caused by selective and relative resistance of these cells to the inhibitory effects of thyroid hormones. 3) Congenital hypothyroidism is not associated with abnormal somatotroph cell responses to TRH.

Authors

Sack J
No affiliation info available
Shafrir Y
No affiliation info available
Urbach D
No affiliation info available
Amado O
No affiliation info available

MeSH

AdolescentChildChild, PreschoolCongenital HypothyroidismFemaleGrowth HormoneHumansHypothyroidismInfantMaleProlactinThyroid GlandThyrotropinThyrotropin-Releasing HormoneThyroxineTriiodothyronine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3932951

Citation

Sack, J, et al. "Thyroid-stimulating Hormone, Prolactin, and Growth Hormone Response to Thyrotropin-releasing Hormone in Treated Children With Congenital Hypothyroidism." Pediatric Research, vol. 19, no. 10, 1985, pp. 1037-9.
Sack J, Shafrir Y, Urbach D, et al. Thyroid-stimulating hormone, prolactin, and growth hormone response to thyrotropin-releasing hormone in treated children with congenital hypothyroidism. Pediatr Res. 1985;19(10):1037-9.
Sack, J., Shafrir, Y., Urbach, D., & Amado, O. (1985). Thyroid-stimulating hormone, prolactin, and growth hormone response to thyrotropin-releasing hormone in treated children with congenital hypothyroidism. Pediatric Research, 19(10), 1037-9.
Sack J, et al. Thyroid-stimulating Hormone, Prolactin, and Growth Hormone Response to Thyrotropin-releasing Hormone in Treated Children With Congenital Hypothyroidism. Pediatr Res. 1985;19(10):1037-9. PubMed PMID: 3932951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid-stimulating hormone, prolactin, and growth hormone response to thyrotropin-releasing hormone in treated children with congenital hypothyroidism. AU - Sack,J, AU - Shafrir,Y, AU - Urbach,D, AU - Amado,O, PY - 1985/10/1/pubmed PY - 1985/10/1/medline PY - 1985/10/1/entrez SP - 1037 EP - 9 JF - Pediatric research JO - Pediatr Res VL - 19 IS - 10 N2 - The purpose of the present study was to assess thyroid-stimulating hormone (TSH), prolactin, and growth hormone responses to TRH stimulation in 12 congenitally hypothyroid children adequately treated with L-thyroxine from the first weeks of life. Although clinically euthyroid, six of these children were found to have abnormally high basal serum TSH concentrations despite clinical euthyroidism. Serum triiodothyroxine and L-thyroxine concentrations were normal and did not differ whether the children had elevated or normal basal serum TSH. All six of the children with high basal TSH had an exaggerated TSH response to TRH and 4 of them also had an augmented prolactin response to TRH. The children with normal basal TSH concentrations had normal TSH and prolactin responses to TRH. An abnormal ("paradoxical") elevation of growth hormone concentration in response to TRH was found in four of seven children in a separate group of patients who had prolonged, untreated primary hypothyroidism, but such responses were not found in any of the adequately treated children. These findings suggest the following conclusions: 1) the phenomenon of high serum concentrations of TSH in conjunction with normal L-thyroxine and triiodothyronine levels (and clinical euthyroidism), is prevalent in congenital hypothyroid patients. 2) These patients have an exaggerated response of their pituitary thyrotroph and lactotroph cells to TRH, presumably caused by selective and relative resistance of these cells to the inhibitory effects of thyroid hormones. 3) Congenital hypothyroidism is not associated with abnormal somatotroph cell responses to TRH. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/3932951/Thyroid_stimulating_hormone_prolactin_and_growth_hormone_response_to_thyrotropin_releasing_hormone_in_treated_children_with_congenital_hypothyroidism_ DB - PRIME DP - Unbound Medicine ER -