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Immunological studies on aphthous ulcer and erythema nodosum-like eruptions in Behcet's disease.
Br J Dermatol. 1985 Sep; 113(3):303-12.BJ

Abstract

Patients with Behcet's disease show an intense delayed hypersensitivity (DH) reaction to a group of streptococcal bacteria. We have attempted to detect deposits of immune complexes and to analyse cytological reactions in the aphthous ulcers and erythema nodosum (EN)-like eruptions. Deposits of IgM and positive fluorescence of anti-streptococcal group D serum were found in vessel walls and sites infiltrated by inflammatory cells. Cytological analysis has revealed that the inflammatory infiltrating cells are mainly composed of activated T-cells and macrophages in association with natural killer cells. These results suggest that DH reactions with antigen-antibody mediated cytotoxicity may play an important role in causing the lesions of Behcet's disease.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3933539

Citation

Kaneko, F, et al. "Immunological Studies On Aphthous Ulcer and Erythema Nodosum-like Eruptions in Behcet's Disease." The British Journal of Dermatology, vol. 113, no. 3, 1985, pp. 303-12.
Kaneko F, Takahashi Y, Muramatsu Y, et al. Immunological studies on aphthous ulcer and erythema nodosum-like eruptions in Behcet's disease. Br J Dermatol. 1985;113(3):303-12.
Kaneko, F., Takahashi, Y., Muramatsu, Y., & Miura, Y. (1985). Immunological studies on aphthous ulcer and erythema nodosum-like eruptions in Behcet's disease. The British Journal of Dermatology, 113(3), 303-12.
Kaneko F, et al. Immunological Studies On Aphthous Ulcer and Erythema Nodosum-like Eruptions in Behcet's Disease. Br J Dermatol. 1985;113(3):303-12. PubMed PMID: 3933539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunological studies on aphthous ulcer and erythema nodosum-like eruptions in Behcet's disease. AU - Kaneko,F, AU - Takahashi,Y, AU - Muramatsu,Y, AU - Miura,Y, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 303 EP - 12 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 113 IS - 3 N2 - Patients with Behcet's disease show an intense delayed hypersensitivity (DH) reaction to a group of streptococcal bacteria. We have attempted to detect deposits of immune complexes and to analyse cytological reactions in the aphthous ulcers and erythema nodosum (EN)-like eruptions. Deposits of IgM and positive fluorescence of anti-streptococcal group D serum were found in vessel walls and sites infiltrated by inflammatory cells. Cytological analysis has revealed that the inflammatory infiltrating cells are mainly composed of activated T-cells and macrophages in association with natural killer cells. These results suggest that DH reactions with antigen-antibody mediated cytotoxicity may play an important role in causing the lesions of Behcet's disease. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/3933539/Immunological_studies_on_aphthous_ulcer_and_erythema_nodosum_like_eruptions_in_Behcet's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1985&volume=113&issue=3&spage=303 DB - PRIME DP - Unbound Medicine ER -