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The fall of zinc protoporphyrin levels in workers treated for chronic lead intoxication.
J Occup Med. 1985 Nov; 27(11):816-20.JO

Abstract

A temporal fall of zinc protoporphyrin (ZPP) levels in whole blood was observed in 51 patients with occupational chronic lead intoxication who were removed from exposure, treated with intravenous calcium disodium edetate (EDTA), and followed for periods up to 2,273 days. ZPP levels fell, with a mean half-life of 68 days, to a mean baseline level of 36 micrograms/dl of whole blood. The baseline ZPP level was positively associated with the length of exposure (p less than .01) and the blood lead half-life (p less than .001). The amount of EDTA received had no apparent effect on ZPP levels. These data suggest that the fall of ZPP levels is largely a function of red blood cell turnover. The baseline ZPP level appears to be a useful biologic index of the biologically active pool of lead for at least two years after removal from exposure.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3934354

Citation

Hryhorczuk, D O., et al. "The Fall of Zinc Protoporphyrin Levels in Workers Treated for Chronic Lead Intoxication." Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association, vol. 27, no. 11, 1985, pp. 816-20.
Hryhorczuk DO, Hogan MM, Mallin K, et al. The fall of zinc protoporphyrin levels in workers treated for chronic lead intoxication. J Occup Med. 1985;27(11):816-20.
Hryhorczuk, D. O., Hogan, M. M., Mallin, K., Hessl, S. M., & Orris, P. (1985). The fall of zinc protoporphyrin levels in workers treated for chronic lead intoxication. Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association, 27(11), 816-20.
Hryhorczuk DO, et al. The Fall of Zinc Protoporphyrin Levels in Workers Treated for Chronic Lead Intoxication. J Occup Med. 1985;27(11):816-20. PubMed PMID: 3934354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The fall of zinc protoporphyrin levels in workers treated for chronic lead intoxication. AU - Hryhorczuk,D O, AU - Hogan,M M, AU - Mallin,K, AU - Hessl,S M, AU - Orris,P, PY - 1985/11/1/pubmed PY - 1985/11/1/medline PY - 1985/11/1/entrez SP - 816 EP - 20 JF - Journal of occupational medicine. : official publication of the Industrial Medical Association JO - J Occup Med VL - 27 IS - 11 N2 - A temporal fall of zinc protoporphyrin (ZPP) levels in whole blood was observed in 51 patients with occupational chronic lead intoxication who were removed from exposure, treated with intravenous calcium disodium edetate (EDTA), and followed for periods up to 2,273 days. ZPP levels fell, with a mean half-life of 68 days, to a mean baseline level of 36 micrograms/dl of whole blood. The baseline ZPP level was positively associated with the length of exposure (p less than .01) and the blood lead half-life (p less than .001). The amount of EDTA received had no apparent effect on ZPP levels. These data suggest that the fall of ZPP levels is largely a function of red blood cell turnover. The baseline ZPP level appears to be a useful biologic index of the biologically active pool of lead for at least two years after removal from exposure. SN - 0096-1736 UR - https://www.unboundmedicine.com/medline/citation/3934354/The_fall_of_zinc_protoporphyrin_levels_in_workers_treated_for_chronic_lead_intoxication_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3934354.ui DB - PRIME DP - Unbound Medicine ER -