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Comparison of in vitro jejunal uptake of L-valine and L-lysine in the rat during maturation.
J Pediatr Gastroenterol Nutr. 1985 Dec; 4(6):992-7.JP

Abstract

The maturational characteristics and patterns of absorption of the neutral amino acid L-valine were compared with those of the basic amino acid L-lysine using in vitro preparations of everted sacs obtained from the jejunum of suckling (2 weeks old), weanling (3 weeks old), and adolescent (6 weeks old) rats. Absorption rates determined as net transport into sac fluid and mucosal uptake (mumol/h/g protein or weight of mucosal scrapings) for both valine and lysine were greater in the suckling than in the weanling or adolescent rats. This appeared to be true for both the carrier-mediated and the diffusive processes for absorption, determined from the relationship between the observed absorption rates and the corresponding mucosal incubation medium amino acid concentrations. The major decline in rate of absorption occurred before the period of weaning. Between the period of suckling and adolescence the carrier-mediated absorption decreased by 55% for valine and by 90% for lysine, suggesting that during maturation of the jejunum the number of the carrier macromolecules responsible for absorption of valine and lysine per unit protein or weight of mucosa decreases with increasing age.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3934359

Citation

Younoszai, M K., et al. "Comparison of in Vitro Jejunal Uptake of L-valine and L-lysine in the Rat During Maturation." Journal of Pediatric Gastroenterology and Nutrition, vol. 4, no. 6, 1985, pp. 992-7.
Younoszai MK, Smith C, Finch MH. Comparison of in vitro jejunal uptake of L-valine and L-lysine in the rat during maturation. J Pediatr Gastroenterol Nutr. 1985;4(6):992-7.
Younoszai, M. K., Smith, C., & Finch, M. H. (1985). Comparison of in vitro jejunal uptake of L-valine and L-lysine in the rat during maturation. Journal of Pediatric Gastroenterology and Nutrition, 4(6), 992-7.
Younoszai MK, Smith C, Finch MH. Comparison of in Vitro Jejunal Uptake of L-valine and L-lysine in the Rat During Maturation. J Pediatr Gastroenterol Nutr. 1985;4(6):992-7. PubMed PMID: 3934359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of in vitro jejunal uptake of L-valine and L-lysine in the rat during maturation. AU - Younoszai,M K, AU - Smith,C, AU - Finch,M H, PY - 1985/12/1/pubmed PY - 1985/12/1/medline PY - 1985/12/1/entrez SP - 992 EP - 7 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 4 IS - 6 N2 - The maturational characteristics and patterns of absorption of the neutral amino acid L-valine were compared with those of the basic amino acid L-lysine using in vitro preparations of everted sacs obtained from the jejunum of suckling (2 weeks old), weanling (3 weeks old), and adolescent (6 weeks old) rats. Absorption rates determined as net transport into sac fluid and mucosal uptake (mumol/h/g protein or weight of mucosal scrapings) for both valine and lysine were greater in the suckling than in the weanling or adolescent rats. This appeared to be true for both the carrier-mediated and the diffusive processes for absorption, determined from the relationship between the observed absorption rates and the corresponding mucosal incubation medium amino acid concentrations. The major decline in rate of absorption occurred before the period of weaning. Between the period of suckling and adolescence the carrier-mediated absorption decreased by 55% for valine and by 90% for lysine, suggesting that during maturation of the jejunum the number of the carrier macromolecules responsible for absorption of valine and lysine per unit protein or weight of mucosa decreases with increasing age. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/3934359/Comparison_of_in_vitro_jejunal_uptake_of_L_valine_and_L_lysine_in_the_rat_during_maturation_ DB - PRIME DP - Unbound Medicine ER -