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Pituitary and ovarian function in women receiving hormonal contraception.
Contraception. 1979 Nov; 20(5):475-87.C

Abstract

A study was performed to further evaluate pituitary-ovarian function in women receiving an oral contraceptive preparation. Basal hormone levels (follicle stimulating hormone, luteinizing hormone, estradiol and prolactin) and gonadotropic response to gonadotropic releasing hormone were studied in 12 healthy, regularly ovulating women in the early follicular and mid-luteal phases of their menstrual cycle (non-treatment control period). These same women were then given NORDETTE (ethinyl estradiol 30 microgram +d-Norgestrel 150 microgram) cyclically for 3 months. In the third month of treatment, the tests were repeated on day 21, i.e. after 21 active pills, and on day 28, i.e. after 21 active and 7 inactive tablets. On active preparation, basal luteinizing hormone, follicle stimulating hormone and estradiol and gonadotropin response to gonadotropin releasing hormone were significantly suppressed. However, by day 28 (after completion of the inactive tablets), basal gonadotropin and estradiol concentrations and the gonadotropic response to gonadotropic releasing hormone were not significantly different to their pretreatment levels. No consistent change in prolactin concentration occurred as a result of oral contraceptive therapy. These results indicate that the 'active' component of even a relatively low-dose pill causes considerable suppression of pituitary-ovarian function but that after 7 days of placebo, pituitary function and basal estradiol secretion have virtually returned to normal.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

393456

Citation

Cohen, B L., and M Katz. "Pituitary and Ovarian Function in Women Receiving Hormonal Contraception." Contraception, vol. 20, no. 5, 1979, pp. 475-87.
Cohen BL, Katz M. Pituitary and ovarian function in women receiving hormonal contraception. Contraception. 1979;20(5):475-87.
Cohen, B. L., & Katz, M. (1979). Pituitary and ovarian function in women receiving hormonal contraception. Contraception, 20(5), 475-87.
Cohen BL, Katz M. Pituitary and Ovarian Function in Women Receiving Hormonal Contraception. Contraception. 1979;20(5):475-87. PubMed PMID: 393456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pituitary and ovarian function in women receiving hormonal contraception. AU - Cohen,B L, AU - Katz,M, PY - 1979/11/1/pubmed PY - 1979/11/1/medline PY - 1979/11/1/entrez KW - Biology KW - Clinical Research KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods--pharmacodynamics KW - Endocrine System KW - Ethinyl Estradiol KW - Family Planning KW - Follicle Stimulating Hormone--analysis KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Levonorgestrel KW - Luteinizing Hormone--analysis KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Low-dose KW - Oral Contraceptives--pharmacodynamics KW - Physiology KW - Pituitary Hormone Releasing Hormones--administraction and dosage KW - Pituitary Hormones KW - Prolactin--analysis KW - Research Methodology SP - 475 EP - 87 JF - Contraception JO - Contraception VL - 20 IS - 5 N2 - A study was performed to further evaluate pituitary-ovarian function in women receiving an oral contraceptive preparation. Basal hormone levels (follicle stimulating hormone, luteinizing hormone, estradiol and prolactin) and gonadotropic response to gonadotropic releasing hormone were studied in 12 healthy, regularly ovulating women in the early follicular and mid-luteal phases of their menstrual cycle (non-treatment control period). These same women were then given NORDETTE (ethinyl estradiol 30 microgram +d-Norgestrel 150 microgram) cyclically for 3 months. In the third month of treatment, the tests were repeated on day 21, i.e. after 21 active pills, and on day 28, i.e. after 21 active and 7 inactive tablets. On active preparation, basal luteinizing hormone, follicle stimulating hormone and estradiol and gonadotropin response to gonadotropin releasing hormone were significantly suppressed. However, by day 28 (after completion of the inactive tablets), basal gonadotropin and estradiol concentrations and the gonadotropic response to gonadotropic releasing hormone were not significantly different to their pretreatment levels. No consistent change in prolactin concentration occurred as a result of oral contraceptive therapy. These results indicate that the 'active' component of even a relatively low-dose pill causes considerable suppression of pituitary-ovarian function but that after 7 days of placebo, pituitary function and basal estradiol secretion have virtually returned to normal. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/393456/Pituitary_and_ovarian_function_in_women_receiving_hormonal_contraception_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(79)90053-2 DB - PRIME DP - Unbound Medicine ER -