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Depressed follicle-stimulating hormone, luteinizing hormone, and prolactin responses to the luteinizing hormone-releasing hormone, thyrotropin-releasing hormone, and metoclopramide test in endurance runners in the hard-training season.
Fertil Steril. 1985 Dec; 44(6):755-9.FS

Abstract

The responses of serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to luteinizing hormone-releasing hormone (LH-RH) and the responses of prolactin (PRL) to thyrotropin-releasing hormone (TRH) and metoclopramide (MC) were measured in the late luteal phase of the cycle in 12 endurance runners and 11 control women and in 12 joggers and 7 control women. LH-RH (100 micrograms) and TRH (200 micrograms) were injected intravenously at the beginning of the test, and MC (10 mg) was injected 60 minutes later. Blood samples were obtained before and 20, 60, 80, and 120 minutes after the beginning of the test. Runners had significantly lower serum concentrations of estradiol and progesterone than control subjects, whereas the concentrations of FSH, LH, and PRL were similar at the beginning of the study. Compared with their controls, the runners had significantly lower FSH (P less than 0.05) and LH responses at 20 minutes (P less than 0.05) and lower LH responses at 80 minutes (P less than 0.01) to LH-RH and lower PRL responses to MC 20 minutes after MC injection (P less than 0.05). Joggers and their control subjects had similar LH, FSH, and PRL responses to these pharmacologic stimuli. It is concluded that decreased ovarian activity explains, at least partly, the lowered responses of FSH and LH to LH-RH and the lowered response of PRL to MC in endurance runners.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3935485

Citation

Ronkainen, H. "Depressed Follicle-stimulating Hormone, Luteinizing Hormone, and Prolactin Responses to the Luteinizing Hormone-releasing Hormone, Thyrotropin-releasing Hormone, and Metoclopramide Test in Endurance Runners in the Hard-training Season." Fertility and Sterility, vol. 44, no. 6, 1985, pp. 755-9.
Ronkainen H. Depressed follicle-stimulating hormone, luteinizing hormone, and prolactin responses to the luteinizing hormone-releasing hormone, thyrotropin-releasing hormone, and metoclopramide test in endurance runners in the hard-training season. Fertil Steril. 1985;44(6):755-9.
Ronkainen, H. (1985). Depressed follicle-stimulating hormone, luteinizing hormone, and prolactin responses to the luteinizing hormone-releasing hormone, thyrotropin-releasing hormone, and metoclopramide test in endurance runners in the hard-training season. Fertility and Sterility, 44(6), 755-9.
Ronkainen H. Depressed Follicle-stimulating Hormone, Luteinizing Hormone, and Prolactin Responses to the Luteinizing Hormone-releasing Hormone, Thyrotropin-releasing Hormone, and Metoclopramide Test in Endurance Runners in the Hard-training Season. Fertil Steril. 1985;44(6):755-9. PubMed PMID: 3935485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressed follicle-stimulating hormone, luteinizing hormone, and prolactin responses to the luteinizing hormone-releasing hormone, thyrotropin-releasing hormone, and metoclopramide test in endurance runners in the hard-training season. A1 - Ronkainen,H, PY - 1985/12/1/pubmed PY - 1985/12/1/medline PY - 1985/12/1/entrez SP - 755 EP - 9 JF - Fertility and sterility JO - Fertil Steril VL - 44 IS - 6 N2 - The responses of serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to luteinizing hormone-releasing hormone (LH-RH) and the responses of prolactin (PRL) to thyrotropin-releasing hormone (TRH) and metoclopramide (MC) were measured in the late luteal phase of the cycle in 12 endurance runners and 11 control women and in 12 joggers and 7 control women. LH-RH (100 micrograms) and TRH (200 micrograms) were injected intravenously at the beginning of the test, and MC (10 mg) was injected 60 minutes later. Blood samples were obtained before and 20, 60, 80, and 120 minutes after the beginning of the test. Runners had significantly lower serum concentrations of estradiol and progesterone than control subjects, whereas the concentrations of FSH, LH, and PRL were similar at the beginning of the study. Compared with their controls, the runners had significantly lower FSH (P less than 0.05) and LH responses at 20 minutes (P less than 0.05) and lower LH responses at 80 minutes (P less than 0.01) to LH-RH and lower PRL responses to MC 20 minutes after MC injection (P less than 0.05). Joggers and their control subjects had similar LH, FSH, and PRL responses to these pharmacologic stimuli. It is concluded that decreased ovarian activity explains, at least partly, the lowered responses of FSH and LH to LH-RH and the lowered response of PRL to MC in endurance runners. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/3935485/Depressed_follicle_stimulating_hormone_luteinizing_hormone_and_prolactin_responses_to_the_luteinizing_hormone_releasing_hormone_thyrotropin_releasing_hormone_and_metoclopramide_test_in_endurance_runners_in_the_hard_training_season_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)49033-3 DB - PRIME DP - Unbound Medicine ER -