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A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes.
Diabetologia. 1985 Dec; 28(12):891-4.D

Abstract

We have been using human T-lymphocyte clones specifically sensitized to detect leucocyte antigens of Type 1 (insulin-dependent) diabetic patients in the hope of detecting novel HLA antigens associated with Type 1 diabetes. We previously described two such clones which define a new class II HLA antigen, Boston-1 (BO1). BO1 is found mainly on cells of persons with particular HLA-DR antigens and, of potential significance for diabetes, BO1 identifies a distinctive subset of DR3 haplotypes. We report here that BO1+ DR3 haplotypes are overrepresented in Type 1 diabetes. That is, significantly more of the DR3-positive subjects are BO1-positive in the patient group (31%) than in the control group (8%), suggesting that a diabetes-susceptibility gene may be more common on the BO1+ than on the BO1- DR3 haplotypes. Alternative interpretations are also discussed.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3937758

Citation

Sheehy, M J., et al. "A Minor Subset of HLA-DR3 Haplotypes Is Preferentially Increased in Type 1 (insulin-dependent) Diabetes." Diabetologia, vol. 28, no. 12, 1985, pp. 891-4.
Sheehy MJ, Rowe JR, Fuller TC, et al. A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes. Diabetologia. 1985;28(12):891-4.
Sheehy, M. J., Rowe, J. R., Fuller, T. C., Yunis, E. J., & Gabbay, K. H. (1985). A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes. Diabetologia, 28(12), 891-4.
Sheehy MJ, et al. A Minor Subset of HLA-DR3 Haplotypes Is Preferentially Increased in Type 1 (insulin-dependent) Diabetes. Diabetologia. 1985;28(12):891-4. PubMed PMID: 3937758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes. AU - Sheehy,M J, AU - Rowe,J R, AU - Fuller,T C, AU - Yunis,E J, AU - Gabbay,K H, PY - 1985/12/1/pubmed PY - 1985/12/1/medline PY - 1985/12/1/entrez SP - 891 EP - 4 JF - Diabetologia JO - Diabetologia VL - 28 IS - 12 N2 - We have been using human T-lymphocyte clones specifically sensitized to detect leucocyte antigens of Type 1 (insulin-dependent) diabetic patients in the hope of detecting novel HLA antigens associated with Type 1 diabetes. We previously described two such clones which define a new class II HLA antigen, Boston-1 (BO1). BO1 is found mainly on cells of persons with particular HLA-DR antigens and, of potential significance for diabetes, BO1 identifies a distinctive subset of DR3 haplotypes. We report here that BO1+ DR3 haplotypes are overrepresented in Type 1 diabetes. That is, significantly more of the DR3-positive subjects are BO1-positive in the patient group (31%) than in the control group (8%), suggesting that a diabetes-susceptibility gene may be more common on the BO1+ than on the BO1- DR3 haplotypes. Alternative interpretations are also discussed. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/3937758/A_minor_subset_of_HLA_DR3_haplotypes_is_preferentially_increased_in_type_1__insulin_dependent__diabetes_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -