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Pentoxifylline -- a biomedical profile.
J Med 1979; 10(5):307-29JM

Abstract

The therapeutical benefit of pentoxifylline (Trental) in vascular disorders and chronic diseases which provoke disturbances in nutritive microcirculation is reviewed. With its hemorheological activity, pentoxifylline offers a new approach to ameliorate impaired blood flow in affected microvasculature. This statement is given evidence by numerous experimental and clinical data which demonstrate efficacy in various indications, wuch as cerebrovascular insufficiency, senile organic brain syndrome, transient ischemic attacks, cerebral infarctus, ocular and otological circulatory disorders, peripheral angiopathies of arteriosclerotic, diabetic, or inflammatory origin with intermittent claudication, leg ulcers and other disturbances. In vitro and in vivo findings disclose that the efficacy is based on hemorheological effects, such as improving local hyperviscosity, hyperaggregability of red cells or platelets, erythrocyte fluidity and hypercoagulability resulting in a better oxygenation of affected tissues.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

393789

Citation

Müller, R. "Pentoxifylline -- a Biomedical Profile." Journal of Medicine, vol. 10, no. 5, 1979, pp. 307-29.
Müller R. Pentoxifylline -- a biomedical profile. J Med. 1979;10(5):307-29.
Müller, R. (1979). Pentoxifylline -- a biomedical profile. Journal of Medicine, 10(5), pp. 307-29.
Müller R. Pentoxifylline -- a Biomedical Profile. J Med. 1979;10(5):307-29. PubMed PMID: 393789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pentoxifylline -- a biomedical profile. A1 - Müller,R, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 307 EP - 29 JF - Journal of medicine JO - J Med VL - 10 IS - 5 N2 - The therapeutical benefit of pentoxifylline (Trental) in vascular disorders and chronic diseases which provoke disturbances in nutritive microcirculation is reviewed. With its hemorheological activity, pentoxifylline offers a new approach to ameliorate impaired blood flow in affected microvasculature. This statement is given evidence by numerous experimental and clinical data which demonstrate efficacy in various indications, wuch as cerebrovascular insufficiency, senile organic brain syndrome, transient ischemic attacks, cerebral infarctus, ocular and otological circulatory disorders, peripheral angiopathies of arteriosclerotic, diabetic, or inflammatory origin with intermittent claudication, leg ulcers and other disturbances. In vitro and in vivo findings disclose that the efficacy is based on hemorheological effects, such as improving local hyperviscosity, hyperaggregability of red cells or platelets, erythrocyte fluidity and hypercoagulability resulting in a better oxygenation of affected tissues. SN - 0025-7850 UR - https://www.unboundmedicine.com/medline/citation/393789/Pentoxifylline____a_biomedical_profile_ DB - PRIME DP - Unbound Medicine ER -