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Pharmacological restoration of scopolamine-impaired memory.
Acta Physiol Pharmacol Bulg. 1985; 11(3):37-43.AP

Abstract

In training for passive avoidance using a device of the step-down type, the nootropic agents piracetam (60 mg/kg orally) and centrophenoxine (100 mg/kg, i. p.) do not facilitate learning, while the ergot alkaloid elymoclavine (1 mg/kg, i. p.) tends to have a positive effect on learning and memory. The muscarine cholinergic receptor blocker scopolamine (2 mg/kg, i. p.) substantially deteriorates short-term memory in passive avoidance training. Piracetam in a dose of 600 mg/kg does not change the negative effect of scopolamine on the memory, while centrophenoxine (100 mg/kg) and elymoclavine (1 mg/kg) eliminate it in view of the fact that the impairment of the short-term memory in the reported experiments was induced by the cholinolytic agent scopolamine, it should be assumed that the observed effects of piracetam, centrophenoxine and elymoclavine are due to definite interactions between the cerebral cholinergic and monoaminergic mechanisms.

Authors

Petkov VV
No affiliation info available
Vuglenova Y
No affiliation info available

MeSH

AnimalsAvoidance LearningErgolinesGlycolatesMaleMeclofenoxateMemory, Short-TermPiracetamPyrrolidinonesRatsRats, Inbred StrainsScopolamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3938594

Citation

Petkov, V V., and Y Vuglenova. "Pharmacological Restoration of Scopolamine-impaired Memory." Acta Physiologica Et Pharmacologica Bulgarica, vol. 11, no. 3, 1985, pp. 37-43.
Petkov VV, Vuglenova Y. Pharmacological restoration of scopolamine-impaired memory. Acta Physiol Pharmacol Bulg. 1985;11(3):37-43.
Petkov, V. V., & Vuglenova, Y. (1985). Pharmacological restoration of scopolamine-impaired memory. Acta Physiologica Et Pharmacologica Bulgarica, 11(3), 37-43.
Petkov VV, Vuglenova Y. Pharmacological Restoration of Scopolamine-impaired Memory. Acta Physiol Pharmacol Bulg. 1985;11(3):37-43. PubMed PMID: 3938594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological restoration of scopolamine-impaired memory. AU - Petkov,V V, AU - Vuglenova,Y, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 37 EP - 43 JF - Acta physiologica et pharmacologica Bulgarica JO - Acta Physiol Pharmacol Bulg VL - 11 IS - 3 N2 - In training for passive avoidance using a device of the step-down type, the nootropic agents piracetam (60 mg/kg orally) and centrophenoxine (100 mg/kg, i. p.) do not facilitate learning, while the ergot alkaloid elymoclavine (1 mg/kg, i. p.) tends to have a positive effect on learning and memory. The muscarine cholinergic receptor blocker scopolamine (2 mg/kg, i. p.) substantially deteriorates short-term memory in passive avoidance training. Piracetam in a dose of 600 mg/kg does not change the negative effect of scopolamine on the memory, while centrophenoxine (100 mg/kg) and elymoclavine (1 mg/kg) eliminate it in view of the fact that the impairment of the short-term memory in the reported experiments was induced by the cholinolytic agent scopolamine, it should be assumed that the observed effects of piracetam, centrophenoxine and elymoclavine are due to definite interactions between the cerebral cholinergic and monoaminergic mechanisms. SN - 0323-9950 UR - https://www.unboundmedicine.com/medline/citation/3938594/Pharmacological_restoration_of_scopolamine_impaired_memory_ DB - PRIME DP - Unbound Medicine ER -