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Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism.
J Endocrinol Invest 1985; 8(6):527-32JE

Abstract

The pituitary and peripheral responses to L-T4 and L-T3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset hypothyroidism, after they had had their chronic thyroid hormone replacement therapy discontinued for 30 days. They were first treated with increasing L-T4 (0.1, 0.2 and 0.4 mg daily) followed by L-T3 (0.05 and 0.2 mg daily) after stopping thyroid medication for another month. Ten normal subjects were treated identically. In normal individuals the peak TSH, alpha, and TSH-beta response to TRH was significantly decreased with 0.1 mg L-T4 or 0.05 mg L-T3 daily and was suppressed with 0.2 and 0.4 mg L-T4 or 0.2 mg L-T3 daily; serum cholesterol and triglyceride decreased significantly with 0.2 or 0.4 mg L-T4 or 0.2 mg L-T3 daily; testosterone-estradiol binding globulin (TeBG) increased significantly at the same doses. In congenitally hypothyroid patients receiving 0.2 mg L-T4 daily, the mean peak TSH after TRH was 24 +/- 17 microU/ml, whereas in patients with an ectopic thyroid or adult-onset hypothyroidism the peak TSH was significantly less at 5.9 +/- 8.8 and 5.5 +/- 5.7 microU/ml, respectively. Only at the highest doses of L-T4 (0.4 mg/day) or L-T3 (0.2 mg/day) was the TSH response to TRH suppressed in the congenitally hypothyroid group. The alpha and TSH-beta subunit levels followed those of TSH.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3938790

Citation

Cavaliere, H, et al. "Persistent Pituitary Resistance to Thyroid Hormone in Congenital Versus Later-onset Hypothyroidism." Journal of Endocrinological Investigation, vol. 8, no. 6, 1985, pp. 527-32.
Cavaliere H, Medeiros-Neto GA, Rosner W, et al. Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism. J Endocrinol Invest. 1985;8(6):527-32.
Cavaliere, H., Medeiros-Neto, G. A., Rosner, W., & Kourides, I. A. (1985). Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism. Journal of Endocrinological Investigation, 8(6), pp. 527-32.
Cavaliere H, et al. Persistent Pituitary Resistance to Thyroid Hormone in Congenital Versus Later-onset Hypothyroidism. J Endocrinol Invest. 1985;8(6):527-32. PubMed PMID: 3938790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism. AU - Cavaliere,H, AU - Medeiros-Neto,G A, AU - Rosner,W, AU - Kourides,I A, PY - 1985/12/1/pubmed PY - 1985/12/1/medline PY - 1985/12/1/entrez SP - 527 EP - 32 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 8 IS - 6 N2 - The pituitary and peripheral responses to L-T4 and L-T3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset hypothyroidism, after they had had their chronic thyroid hormone replacement therapy discontinued for 30 days. They were first treated with increasing L-T4 (0.1, 0.2 and 0.4 mg daily) followed by L-T3 (0.05 and 0.2 mg daily) after stopping thyroid medication for another month. Ten normal subjects were treated identically. In normal individuals the peak TSH, alpha, and TSH-beta response to TRH was significantly decreased with 0.1 mg L-T4 or 0.05 mg L-T3 daily and was suppressed with 0.2 and 0.4 mg L-T4 or 0.2 mg L-T3 daily; serum cholesterol and triglyceride decreased significantly with 0.2 or 0.4 mg L-T4 or 0.2 mg L-T3 daily; testosterone-estradiol binding globulin (TeBG) increased significantly at the same doses. In congenitally hypothyroid patients receiving 0.2 mg L-T4 daily, the mean peak TSH after TRH was 24 +/- 17 microU/ml, whereas in patients with an ectopic thyroid or adult-onset hypothyroidism the peak TSH was significantly less at 5.9 +/- 8.8 and 5.5 +/- 5.7 microU/ml, respectively. Only at the highest doses of L-T4 (0.4 mg/day) or L-T3 (0.2 mg/day) was the TSH response to TRH suppressed in the congenitally hypothyroid group. The alpha and TSH-beta subunit levels followed those of TSH.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/3938790/Persistent_pituitary_resistance_to_thyroid_hormone_in_congenital_versus_later_onset_hypothyroidism_ L2 - https://link.springer.com/article/10.1007/bf03348554 DB - PRIME DP - Unbound Medicine ER -