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Caffeine consumption during pregnancy and association with late spontaneous abortion.
Am J Obstet Gynecol. 1986 Jan; 154(1):14-20.AJ

Abstract

In a prospective cohort study, 3135 pregnant women were followed to evaluate the association of caffeine consumption during pregnancy with late first- and second-trimester spontaneous abortion. Almost 80% of pregnant women used some caffeine; among users the average daily intake was 99.3 mg from all sources. Sources of caffeine were nonherbal tea (used by 49.4% of women), coffee (41.2%), colas (35.0%), and drugs (6.6%). In all, 28% of pregnant women consumed greater than or equal to 151 mg of caffeine daily, and these "moderate-to-heavy" caffeine users were significantly more likely to experience late first- or second-trimester spontaneous abortion when compared with nonusers and light users (0 to 150 mg). Demographic characteristics, reproductive and medical history, contraceptive use, and smoking and drinking habits were taken into consideration. The adjusted relative risk of miscarriage after moderate-to-heavy caffeine consumption was 1.73 (p = 0.03). Light caffeine use (1 to 150 mg daily) was associated with increased risk for spontaneous abortion only among women who aborted in their last pregnancy (RR = 4.18, p = 0.04). Replicative studies are necessary before the association of caffeine with spontaneous abortion can be confirmed.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3946486

Citation

Srisuphan, W, and M B. Bracken. "Caffeine Consumption During Pregnancy and Association With Late Spontaneous Abortion." American Journal of Obstetrics and Gynecology, vol. 154, no. 1, 1986, pp. 14-20.
Srisuphan W, Bracken MB. Caffeine consumption during pregnancy and association with late spontaneous abortion. Am J Obstet Gynecol. 1986;154(1):14-20.
Srisuphan, W., & Bracken, M. B. (1986). Caffeine consumption during pregnancy and association with late spontaneous abortion. American Journal of Obstetrics and Gynecology, 154(1), 14-20.
Srisuphan W, Bracken MB. Caffeine Consumption During Pregnancy and Association With Late Spontaneous Abortion. Am J Obstet Gynecol. 1986;154(1):14-20. PubMed PMID: 3946486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine consumption during pregnancy and association with late spontaneous abortion. AU - Srisuphan,W, AU - Bracken,M B, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 14 EP - 20 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 154 IS - 1 N2 - In a prospective cohort study, 3135 pregnant women were followed to evaluate the association of caffeine consumption during pregnancy with late first- and second-trimester spontaneous abortion. Almost 80% of pregnant women used some caffeine; among users the average daily intake was 99.3 mg from all sources. Sources of caffeine were nonherbal tea (used by 49.4% of women), coffee (41.2%), colas (35.0%), and drugs (6.6%). In all, 28% of pregnant women consumed greater than or equal to 151 mg of caffeine daily, and these "moderate-to-heavy" caffeine users were significantly more likely to experience late first- or second-trimester spontaneous abortion when compared with nonusers and light users (0 to 150 mg). Demographic characteristics, reproductive and medical history, contraceptive use, and smoking and drinking habits were taken into consideration. The adjusted relative risk of miscarriage after moderate-to-heavy caffeine consumption was 1.73 (p = 0.03). Light caffeine use (1 to 150 mg daily) was associated with increased risk for spontaneous abortion only among women who aborted in their last pregnancy (RR = 4.18, p = 0.04). Replicative studies are necessary before the association of caffeine with spontaneous abortion can be confirmed. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/3946486/Caffeine_consumption_during_pregnancy_and_association_with_late_spontaneous_abortion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(86)90385-6 DB - PRIME DP - Unbound Medicine ER -