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Counterregulatory system in an artificial endocrine pancreas. Glucose infusion algorithm.
Artif Organs. 1979 Aug; 3(3):265-70.AO

Abstract

An artificial endocrine pancreas has been developed by adding a glucose infusion system to the artificial beta cell system. In this computer algorithm, glucose is infused on the basis of proportional and derivative actions to blood glucose concentration with the time delay constant between blood withdrawal and initiation of glucose infusion. When glucose was infused on the basis of proportional action with a 20-minute time delay, the prompt restoration to normoglycemia from the hypoglycemic state with a smaller amount of glucose was shown in depancreatized dogs. These results indicate that the artificial endocrine pancreas thus prepared is not only a useful device to safely control blood glucose, but also is an efficient research tool for the analysis of the blood glucose regulatory mechanism.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

394725

Citation

Yamasaki, Y, et al. "Counterregulatory System in an Artificial Endocrine Pancreas. Glucose Infusion Algorithm." Artificial Organs, vol. 3, no. 3, 1979, pp. 265-70.
Yamasaki Y, Shichiri M, Kawamori R, et al. Counterregulatory system in an artificial endocrine pancreas. Glucose infusion algorithm. Artif Organs. 1979;3(3):265-70.
Yamasaki, Y., Shichiri, M., Kawamori, R., Goriya, Y., Sasai, T., Morishima, T., Nomura, M., Tohdo, R., & Abe, H. (1979). Counterregulatory system in an artificial endocrine pancreas. Glucose infusion algorithm. Artificial Organs, 3(3), 265-70.
Yamasaki Y, et al. Counterregulatory System in an Artificial Endocrine Pancreas. Glucose Infusion Algorithm. Artif Organs. 1979;3(3):265-70. PubMed PMID: 394725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Counterregulatory system in an artificial endocrine pancreas. Glucose infusion algorithm. AU - Yamasaki,Y, AU - Shichiri,M, AU - Kawamori,R, AU - Goriya,Y, AU - Sasai,T, AU - Morishima,T, AU - Nomura,M, AU - Tohdo,R, AU - Abe,H, PY - 1979/8/1/pubmed PY - 1979/8/1/medline PY - 1979/8/1/entrez SP - 265 EP - 70 JF - Artificial organs JO - Artif Organs VL - 3 IS - 3 N2 - An artificial endocrine pancreas has been developed by adding a glucose infusion system to the artificial beta cell system. In this computer algorithm, glucose is infused on the basis of proportional and derivative actions to blood glucose concentration with the time delay constant between blood withdrawal and initiation of glucose infusion. When glucose was infused on the basis of proportional action with a 20-minute time delay, the prompt restoration to normoglycemia from the hypoglycemic state with a smaller amount of glucose was shown in depancreatized dogs. These results indicate that the artificial endocrine pancreas thus prepared is not only a useful device to safely control blood glucose, but also is an efficient research tool for the analysis of the blood glucose regulatory mechanism. SN - 0160-564X UR - https://www.unboundmedicine.com/medline/citation/394725/Counterregulatory_system_in_an_artificial_endocrine_pancreas__Glucose_infusion_algorithm_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0160-564X&date=1979&volume=3&issue=3&spage=265 DB - PRIME DP - Unbound Medicine ER -