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Necrobiotic xanthogranuloma: a report of four cases.

Abstract

Four patients are described who demonstrate the range of clinical and pathological features seen in necrobiotic xanthogranuloma with paraproteinaemia (NXG). Each patient had the typical periorbital yellow plaques with numerous well demarcated yellow indurated plaques on the trunk. All four patients had evidence of paraproteinaemia. The histopathology showed diagnostic features of intense necrobiosis with xanthomatization, including touton giant cells and the bizarre angulated giant cells of NXG. Previously, the patients had been diagnosed as atypical necrobiosis lipoidica, and the distinction between NXG and other necrobiotic conditions is discussed.

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  • Authors

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    Source

    The British journal of dermatology 114:2 1986 Feb pg 241-50

    MeSH

    Aged
    Diagnosis, Differential
    Female
    Granuloma
    Humans
    Middle Aged
    Necrobiosis Lipoidica
    Skin
    Xanthomatosis

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    3947540

    Citation

    Holden, C A., et al. "Necrobiotic Xanthogranuloma: a Report of Four Cases." The British Journal of Dermatology, vol. 114, no. 2, 1986, pp. 241-50.
    Holden CA, Winkelmann RK, Wilson Jones E. Necrobiotic xanthogranuloma: a report of four cases. Br J Dermatol. 1986;114(2):241-50.
    Holden, C. A., Winkelmann, R. K., & Wilson Jones, E. (1986). Necrobiotic xanthogranuloma: a report of four cases. The British Journal of Dermatology, 114(2), pp. 241-50.
    Holden CA, Winkelmann RK, Wilson Jones E. Necrobiotic Xanthogranuloma: a Report of Four Cases. Br J Dermatol. 1986;114(2):241-50. PubMed PMID: 3947540.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Necrobiotic xanthogranuloma: a report of four cases. AU - Holden,C A, AU - Winkelmann,R K, AU - Wilson Jones,E, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 241 EP - 50 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 114 IS - 2 N2 - Four patients are described who demonstrate the range of clinical and pathological features seen in necrobiotic xanthogranuloma with paraproteinaemia (NXG). Each patient had the typical periorbital yellow plaques with numerous well demarcated yellow indurated plaques on the trunk. All four patients had evidence of paraproteinaemia. The histopathology showed diagnostic features of intense necrobiosis with xanthomatization, including touton giant cells and the bizarre angulated giant cells of NXG. Previously, the patients had been diagnosed as atypical necrobiosis lipoidica, and the distinction between NXG and other necrobiotic conditions is discussed. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/3947540/Necrobiotic_xanthogranuloma:_a_report_of_four_cases_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1986&volume=114&issue=2&spage=241 DB - PRIME DP - Unbound Medicine ER -