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4-(1-Naphthylvinyl)pyridine decreases brain acetylcholine in vivo, but does not alter the level of acetyl-CoA.
J Neurochem. 1986 Mar; 46(3):990-2.JN

Abstract

The effects of intraperitoneally administered 4-(1-naphthylvinyl)pyridine (NVP; 200 mg/kg) on the concentrations of acetylcholine (ACh), choline (Ch), and acetyl-CoA (AcCoA) in rat striatum, cortex, hippocampus, and cerebellum were investigated. Twenty minutes after treatment, the content of ACh was significantly diminished, whereas that of Ch was increased. In response to stress (swimming for 20 min), these changes were enhanced. However, the AcCoA content did not change in any of the brain regions. It is thus very likely that the decrease of brain ACh concentration induced by NVP is due to the drug's effect on choline acetyltransferase (ChAT) and/or the reduction of the high-affinity Ch uptake, and not on the availability of AcCoA. Presumably, the pharmacologically diminished activity of ChAT may become the rate-limiting factor in the maintenance of ACh levels in cholinergic neurons.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3950616

Citation

Budai, D, et al. "4-(1-Naphthylvinyl)pyridine Decreases Brain Acetylcholine in Vivo, but Does Not Alter the Level of Acetyl-CoA." Journal of Neurochemistry, vol. 46, no. 3, 1986, pp. 990-2.
Budai D, Rícný J, Kása P, et al. 4-(1-Naphthylvinyl)pyridine decreases brain acetylcholine in vivo, but does not alter the level of acetyl-CoA. J Neurochem. 1986;46(3):990-2.
Budai, D., Rícný, J., Kása, P., & Tucek, S. (1986). 4-(1-Naphthylvinyl)pyridine decreases brain acetylcholine in vivo, but does not alter the level of acetyl-CoA. Journal of Neurochemistry, 46(3), 990-2.
Budai D, et al. 4-(1-Naphthylvinyl)pyridine Decreases Brain Acetylcholine in Vivo, but Does Not Alter the Level of Acetyl-CoA. J Neurochem. 1986;46(3):990-2. PubMed PMID: 3950616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 4-(1-Naphthylvinyl)pyridine decreases brain acetylcholine in vivo, but does not alter the level of acetyl-CoA. AU - Budai,D, AU - Rícný,J, AU - Kása,P, AU - Tucek,S, PY - 1986/3/1/pubmed PY - 1986/3/1/medline PY - 1986/3/1/entrez SP - 990 EP - 2 JF - Journal of neurochemistry JO - J Neurochem VL - 46 IS - 3 N2 - The effects of intraperitoneally administered 4-(1-naphthylvinyl)pyridine (NVP; 200 mg/kg) on the concentrations of acetylcholine (ACh), choline (Ch), and acetyl-CoA (AcCoA) in rat striatum, cortex, hippocampus, and cerebellum were investigated. Twenty minutes after treatment, the content of ACh was significantly diminished, whereas that of Ch was increased. In response to stress (swimming for 20 min), these changes were enhanced. However, the AcCoA content did not change in any of the brain regions. It is thus very likely that the decrease of brain ACh concentration induced by NVP is due to the drug's effect on choline acetyltransferase (ChAT) and/or the reduction of the high-affinity Ch uptake, and not on the availability of AcCoA. Presumably, the pharmacologically diminished activity of ChAT may become the rate-limiting factor in the maintenance of ACh levels in cholinergic neurons. SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/3950616/4__1_Naphthylvinyl_pyridine_decreases_brain_acetylcholine_in_vivo_but_does_not_alter_the_level_of_acetyl_CoA_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3042&date=1986&volume=46&issue=3&spage=990 DB - PRIME DP - Unbound Medicine ER -