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D-Trp8-D-Cys14-somatostatin--demonstration of its differential suppressive activity in juvenile diabetics.

Abstract

In 8 insulin-dependent diabetics, the effect of D-Trp8-D-Cys14-somatostatin on blood glucose, growth hormone, and glucagon levels as well as on insulin requirements from an artificial endocrine pancreas was studied during a balanced meal. The somatostatin analogue was infused at a rate of 25 microgram/h preceeded by a bolus injection of 25 microgram 30 minutes before ingestion of the meal. At this dose the analogue had no effect on glucagon levels and insulin requirements from the artificial pancreas. On the other hand, there was a significant lowering effect on fasting blood glucose levels, possibly indicating a direct inhibition of hepatic glucose production. Furthermore, there might be a slight effect on growth hormone levels, as was demonstrated by a rebound increase after termination of analogue infusion.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

395066

Citation

Neuhaus, C, et al. "D-Trp8-D-Cys14-somatostatin--demonstration of Its Differential Suppressive Activity in Juvenile Diabetics." Hormone and Metabolic Research. Supplement Series, 1979, pp. 115-8.
Neuhaus C, Kerner W, Maier V, et al. D-Trp8-D-Cys14-somatostatin--demonstration of its differential suppressive activity in juvenile diabetics. Horm Metab Res Suppl. 1979.
Neuhaus, C., Kerner, W., Maier, V., & Pfeiffer, E. F. (1979). D-Trp8-D-Cys14-somatostatin--demonstration of its differential suppressive activity in juvenile diabetics. Hormone and Metabolic Research. Supplement Series, (8), 115-8.
Neuhaus C, et al. D-Trp8-D-Cys14-somatostatin--demonstration of Its Differential Suppressive Activity in Juvenile Diabetics. Horm Metab Res Suppl. 1979;(8)115-8. PubMed PMID: 395066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - D-Trp8-D-Cys14-somatostatin--demonstration of its differential suppressive activity in juvenile diabetics. AU - Neuhaus,C, AU - Kerner,W, AU - Maier,V, AU - Pfeiffer,E F, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 115 EP - 8 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl IS - 8 N2 - In 8 insulin-dependent diabetics, the effect of D-Trp8-D-Cys14-somatostatin on blood glucose, growth hormone, and glucagon levels as well as on insulin requirements from an artificial endocrine pancreas was studied during a balanced meal. The somatostatin analogue was infused at a rate of 25 microgram/h preceeded by a bolus injection of 25 microgram 30 minutes before ingestion of the meal. At this dose the analogue had no effect on glucagon levels and insulin requirements from the artificial pancreas. On the other hand, there was a significant lowering effect on fasting blood glucose levels, possibly indicating a direct inhibition of hepatic glucose production. Furthermore, there might be a slight effect on growth hormone levels, as was demonstrated by a rebound increase after termination of analogue infusion. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/395066/D_Trp8_D_Cys14_somatostatin__demonstration_of_its_differential_suppressive_activity_in_juvenile_diabetics_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -