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The external artificial pancreas: an instrument to induce remissions in severe recent juvenile diabetes. Comparison with a preprogrammed insulin infusion system.

Abstract

Remission of juvenile insulin-dependent diabetes is a rare, temporary, and partial phenomenon which seems to be related to an improvement of the residual insulin secretion supported by prompt and rigorous insulin therapy. Thus, remissions allowing the replacement of insulin by oral drugs were attempted in 23 insulin dependent ketotic juvenile diabetics (age 10 +/- 2 years) of recent onset (apparent duration of diabetes 71 +/- 5 days) treated by an external artificial pancreas during 5 +/- 1 days and compared with 10 control diabetics treated by a less effective technique (preprogrammed insulin pump without feedback control) during 6 +/- 1 days. 18 (78%) remissions of long duration (1-26 months) occurred after artificial pancreas compared with 3 (30%) in the control group. Measurement of daily urinary C-peptide excretion confirmed the improvement of the residual insulin secretion in patients with insulin-induced remissions. Thus, the excellent blood glucose control given by an artificial pancreas seems necessary to lead to much more frequent remissions of diabetes than usually reported.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

395071

Citation

Mirouze, J, et al. "The External Artificial Pancreas: an Instrument to Induce Remissions in Severe Recent Juvenile Diabetes. Comparison With a Preprogrammed Insulin Infusion System." Hormone and Metabolic Research. Supplement Series, 1979, pp. 141-5.
Mirouze J, Selam JL, Pham TC, et al. The external artificial pancreas: an instrument to induce remissions in severe recent juvenile diabetes. Comparison with a preprogrammed insulin infusion system. Horm Metab Res Suppl. 1979.
Mirouze, J., Selam, J. L., Pham, T. C., & Orsetti, A. (1979). The external artificial pancreas: an instrument to induce remissions in severe recent juvenile diabetes. Comparison with a preprogrammed insulin infusion system. Hormone and Metabolic Research. Supplement Series, (8), 141-5.
Mirouze J, et al. The External Artificial Pancreas: an Instrument to Induce Remissions in Severe Recent Juvenile Diabetes. Comparison With a Preprogrammed Insulin Infusion System. Horm Metab Res Suppl. 1979;(8)141-5. PubMed PMID: 395071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The external artificial pancreas: an instrument to induce remissions in severe recent juvenile diabetes. Comparison with a preprogrammed insulin infusion system. AU - Mirouze,J, AU - Selam,J L, AU - Pham,T C, AU - Orsetti,A, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 141 EP - 5 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl IS - 8 N2 - Remission of juvenile insulin-dependent diabetes is a rare, temporary, and partial phenomenon which seems to be related to an improvement of the residual insulin secretion supported by prompt and rigorous insulin therapy. Thus, remissions allowing the replacement of insulin by oral drugs were attempted in 23 insulin dependent ketotic juvenile diabetics (age 10 +/- 2 years) of recent onset (apparent duration of diabetes 71 +/- 5 days) treated by an external artificial pancreas during 5 +/- 1 days and compared with 10 control diabetics treated by a less effective technique (preprogrammed insulin pump without feedback control) during 6 +/- 1 days. 18 (78%) remissions of long duration (1-26 months) occurred after artificial pancreas compared with 3 (30%) in the control group. Measurement of daily urinary C-peptide excretion confirmed the improvement of the residual insulin secretion in patients with insulin-induced remissions. Thus, the excellent blood glucose control given by an artificial pancreas seems necessary to lead to much more frequent remissions of diabetes than usually reported. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/395071/The_external_artificial_pancreas:_an_instrument_to_induce_remissions_in_severe_recent_juvenile_diabetes__Comparison_with_a_preprogrammed_insulin_infusion_system_ L2 - http://www.diseaseinfosearch.org/result/2242 DB - PRIME DP - Unbound Medicine ER -