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Use of an artificial beta cell in surgery.

Abstract

Using a Biostator glucose-controlled insulin infusion system to monitor blood glucose during surgery, we have shown that both nondiabetic and diabetic patients have a tendency towards hyperglycemia during surgery. This appears to be due to suppression of endogenous insulin secretion as measured by serum C-peptide levels. Some diabetic patients maintained relatively normal glucose values during surgery when infused with saline alone and not given glucose or insulin, but 2 of 5 were not well controlled by this means. Hyperglycemia in both diabetic and non-diabetic patients was related to the rate of infusion of exogenous glucose. The biostator glucose-controlled insulin infusion system could be used in feedback mode as an apparently safe and effective means of controlling blood glucose during surgery on diabetic patients.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

395072

Citation

Horwitz, D L., and S S. Schwartz. "Use of an Artificial Beta Cell in Surgery." Hormone and Metabolic Research. Supplement Series, 1979, pp. 156-8.
Horwitz DL, Schwartz SS. Use of an artificial beta cell in surgery. Horm Metab Res Suppl. 1979.
Horwitz, D. L., & Schwartz, S. S. (1979). Use of an artificial beta cell in surgery. Hormone and Metabolic Research. Supplement Series, (8), 156-8.
Horwitz DL, Schwartz SS. Use of an Artificial Beta Cell in Surgery. Horm Metab Res Suppl. 1979;(8)156-8. PubMed PMID: 395072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of an artificial beta cell in surgery. AU - Horwitz,D L, AU - Schwartz,S S, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 156 EP - 8 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl IS - 8 N2 - Using a Biostator glucose-controlled insulin infusion system to monitor blood glucose during surgery, we have shown that both nondiabetic and diabetic patients have a tendency towards hyperglycemia during surgery. This appears to be due to suppression of endogenous insulin secretion as measured by serum C-peptide levels. Some diabetic patients maintained relatively normal glucose values during surgery when infused with saline alone and not given glucose or insulin, but 2 of 5 were not well controlled by this means. Hyperglycemia in both diabetic and non-diabetic patients was related to the rate of infusion of exogenous glucose. The biostator glucose-controlled insulin infusion system could be used in feedback mode as an apparently safe and effective means of controlling blood glucose during surgery on diabetic patients. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/395072/Use_of_an_artificial_beta_cell_in_surgery_ L2 - https://medlineplus.gov/surgery.html DB - PRIME DP - Unbound Medicine ER -