Tags

Type your tag names separated by a space and hit enter

Continuous intravenous insulin therapy with a miniaturized open-loop system.

Abstract

For the continuous intravenous application of insulin, a portable open-loop system was developed consisting of a delivery unit with a miniaturized pump and an insulin reservoir which is connected with an electronic control unit. The infusion rates were either preprogrammed or patient-controlled. Blood glucose control with both systems was tested in eight juvenile-type diabetics, among them two of the brittle type. Diabetic control during a 1-2-day pre-infusion period was compared with 2-3 days of continuous insulin infusion; as judged by the mean blood glucose value (MBG), the mean amplitude of glycemic excursions (MAGE), and glucosuria, all patients were significantly better controlled by the open-loop systems than by conventional therapy with subcutaneous insulin. The use of portable open-loop systems offers a promising approach to an improvement of metabolic control in insulin-requiring diabetics.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

395077

Citation

Renner, R, et al. "Continuous Intravenous Insulin Therapy With a Miniaturized Open-loop System." Hormone and Metabolic Research. Supplement Series, 1979, pp. 186-90.
Renner R, Hepp KD, Mehnert H, et al. Continuous intravenous insulin therapy with a miniaturized open-loop system. Horm Metab Res Suppl. 1979.
Renner, R., Hepp, K. D., Mehnert, H., & Franetzki, M. (1979). Continuous intravenous insulin therapy with a miniaturized open-loop system. Hormone and Metabolic Research. Supplement Series, (8), 186-90.
Renner R, et al. Continuous Intravenous Insulin Therapy With a Miniaturized Open-loop System. Horm Metab Res Suppl. 1979;(8)186-90. PubMed PMID: 395077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous intravenous insulin therapy with a miniaturized open-loop system. AU - Renner,R, AU - Hepp,K D, AU - Mehnert,H, AU - Franetzki,M, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 186 EP - 90 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl IS - 8 N2 - For the continuous intravenous application of insulin, a portable open-loop system was developed consisting of a delivery unit with a miniaturized pump and an insulin reservoir which is connected with an electronic control unit. The infusion rates were either preprogrammed or patient-controlled. Blood glucose control with both systems was tested in eight juvenile-type diabetics, among them two of the brittle type. Diabetic control during a 1-2-day pre-infusion period was compared with 2-3 days of continuous insulin infusion; as judged by the mean blood glucose value (MBG), the mean amplitude of glycemic excursions (MAGE), and glucosuria, all patients were significantly better controlled by the open-loop systems than by conventional therapy with subcutaneous insulin. The use of portable open-loop systems offers a promising approach to an improvement of metabolic control in insulin-requiring diabetics. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/395077/Continuous_intravenous_insulin_therapy_with_a_miniaturized_open_loop_system_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -