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Development of a closed-loop artificial pancreas.
Horm Metab Res Suppl. 1979HM

Abstract

A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, cost reduction and better performance. The algorithm used was a piecewise linear representation of the sigmoidal curve commonly employed. The apparatus has been applied to simulation of the healthy beta cell and glucose clamp studies.

Authors

Kraegen EW
No affiliation info available
Whiteside R
No affiliation info available
Bell D
No affiliation info available
Chia YO
No affiliation info available
Lazarus L
No affiliation info available

MeSH

Artificial OrgansAutoanalysisBlood GlucoseComputersDiabetes MellitusEatingFeedbackHumansInfusions, ParenteralInsulinIslets of Langerhans

Pub Type(s)

Journal Article

Language

eng

PubMed ID

395087

Citation

Kraegen, E W., et al. "Development of a Closed-loop Artificial Pancreas." Hormone and Metabolic Research. Supplement Series, 1979, pp. 38-42.
Kraegen EW, Whiteside R, Bell D, et al. Development of a closed-loop artificial pancreas. Horm Metab Res Suppl. 1979.
Kraegen, E. W., Whiteside, R., Bell, D., Chia, Y. O., & Lazarus, L. (1979). Development of a closed-loop artificial pancreas. Hormone and Metabolic Research. Supplement Series, (8), 38-42.
Kraegen EW, et al. Development of a Closed-loop Artificial Pancreas. Horm Metab Res Suppl. 1979;(8)38-42. PubMed PMID: 395087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of a closed-loop artificial pancreas. AU - Kraegen,E W, AU - Whiteside,R, AU - Bell,D, AU - Chia,Y O, AU - Lazarus,L, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 38 EP - 42 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl IS - 8 N2 - A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, cost reduction and better performance. The algorithm used was a piecewise linear representation of the sigmoidal curve commonly employed. The apparatus has been applied to simulation of the healthy beta cell and glucose clamp studies. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/395087/Development_of_a_closed_loop_artificial_pancreas_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -