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Variation induced by a three-days application of the artificial beta-cell on glucagon, growth hormone and catecholamine secretion, glycosylated hemoglobin, and erythrocyte 2,3-diphosphoglycerate concentration.

Abstract

Five insulin-dependent diabetics with poor metabolic control were examined at the beginning and after a three-day application of artificial endocrine pancreas (AEP). Pancreatic alpha cell function evaluated by arginine infusion (0.5 g/Kg b.w. over 30 minutes) showed no significant differences between the beginning and during artificial beta cell aplication, but the increment in plasma glucagon level over basal values observed in both tests appeared significantly higher at 30 and 60 min in comparison with a control group. Growth hormone response to arginine infusion was clearly reduced in the second test. C-peptide concentration appeared very low in basal conditions and during arginine infusion; no improvement was observed after three days of AEP application. Urinary excretion of norepinephrine markedly increased at the beginning of the study, reversed almost to normal during AEP treatment, while minor changes were observed in urinary excretion of epinephrine. The Concentration of glycosylated hemoglobin, markedly higher than normally before the connection with AEP, showed a slight but significant decrease during glucose-controlled insulin infusion. Finally, 2,3-diphosphoglycerate was normal and no modifications were observed in the course of the study.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

395095

Citation

Brunetti, P, et al. "Variation Induced By a Three-days Application of the Artificial Beta-cell On Glucagon, Growth Hormone and Catecholamine Secretion, Glycosylated Hemoglobin, and Erythrocyte 2,3-diphosphoglycerate Concentration." Hormone and Metabolic Research. Supplement Series, 1979, pp. 81-6.
Brunetti P, Massi-Benedetti M, Puxeddu A, et al. Variation induced by a three-days application of the artificial beta-cell on glucagon, growth hormone and catecholamine secretion, glycosylated hemoglobin, and erythrocyte 2,3-diphosphoglycerate concentration. Horm Metab Res Suppl. 1979.
Brunetti, P., Massi-Benedetti, M., Puxeddu, A., Santeusanio, F., Calabrese, G., Bolli, G., Scionti, L., & Angeletti, G. (1979). Variation induced by a three-days application of the artificial beta-cell on glucagon, growth hormone and catecholamine secretion, glycosylated hemoglobin, and erythrocyte 2,3-diphosphoglycerate concentration. Hormone and Metabolic Research. Supplement Series, (8), 81-6.
Brunetti P, et al. Variation Induced By a Three-days Application of the Artificial Beta-cell On Glucagon, Growth Hormone and Catecholamine Secretion, Glycosylated Hemoglobin, and Erythrocyte 2,3-diphosphoglycerate Concentration. Horm Metab Res Suppl. 1979;(8)81-6. PubMed PMID: 395095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variation induced by a three-days application of the artificial beta-cell on glucagon, growth hormone and catecholamine secretion, glycosylated hemoglobin, and erythrocyte 2,3-diphosphoglycerate concentration. AU - Brunetti,P, AU - Massi-Benedetti,M, AU - Puxeddu,A, AU - Santeusanio,F, AU - Calabrese,G, AU - Bolli,G, AU - Scionti,L, AU - Angeletti,G, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 81 EP - 6 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl IS - 8 N2 - Five insulin-dependent diabetics with poor metabolic control were examined at the beginning and after a three-day application of artificial endocrine pancreas (AEP). Pancreatic alpha cell function evaluated by arginine infusion (0.5 g/Kg b.w. over 30 minutes) showed no significant differences between the beginning and during artificial beta cell aplication, but the increment in plasma glucagon level over basal values observed in both tests appeared significantly higher at 30 and 60 min in comparison with a control group. Growth hormone response to arginine infusion was clearly reduced in the second test. C-peptide concentration appeared very low in basal conditions and during arginine infusion; no improvement was observed after three days of AEP application. Urinary excretion of norepinephrine markedly increased at the beginning of the study, reversed almost to normal during AEP treatment, while minor changes were observed in urinary excretion of epinephrine. The Concentration of glycosylated hemoglobin, markedly higher than normally before the connection with AEP, showed a slight but significant decrease during glucose-controlled insulin infusion. Finally, 2,3-diphosphoglycerate was normal and no modifications were observed in the course of the study. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/395095/Variation_induced_by_a_three_days_application_of_the_artificial_beta_cell_on_glucagon_growth_hormone_and_catecholamine_secretion_glycosylated_hemoglobin_and_erythrocyte_23_diphosphoglycerate_concentration_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -