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The effect of three days of blood glucose normalization by means of an "artificial endocrine pancreas" on the concentrations of growth hormone, glucagon, and cortisol in juvenile diabetics.

Abstract

Glucagon, growth hormone, and cortisol secretion was studied in seven male insulin-dependent diabetics under conventional subcutaneous insulin therapy and after three days of blood glucose normalization attained by the artificial endocrine pancreas (Biostator-GCIIS). The diurnal hormonal profiles under the two types of therapy were compared. Six healthy male students served as control group. A three-day period of blood glucose normalization in insulin-dependent diabetic can restore glucagon secretion to normal. Growth hormone secretion is decreased but not completely normalised. Cortisol secretion is slightly decreased. It is concluded that prolonged normoglycemia achieved by means of an artificial endocrine pancreas may completely control endocrine abnormalities in insulin-dependent diabetics.

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MeSH

Adult
Artificial Organs
Blood Glucose
Circadian Rhythm
Diabetes Mellitus, Type 1
Feedback
Glucagon
Growth Hormone
Humans
Hydrocortisone
Infusions, Parenteral
Insulin
Islets of Langerhans
Middle Aged

Pub Type(s)

Journal Article

Language

eng

PubMed ID

395097

Citation

Schock, A, et al. "The Effect of Three Days of Blood Glucose Normalization By Means of an "artificial Endocrine Pancreas" On the Concentrations of Growth Hormone, Glucagon, and Cortisol in Juvenile Diabetics." Hormone and Metabolic Research. Supplement Series, 1979, pp. 93-6.
Schock A, Schultz M, Kerner W, et al. The effect of three days of blood glucose normalization by means of an "artificial endocrine pancreas" on the concentrations of growth hormone, glucagon, and cortisol in juvenile diabetics. Horm Metab Res Suppl. 1979.
Schock, A., Schultz, M., Kerner, W., Maier, V., & Pfeiffer, E. F. (1979). The effect of three days of blood glucose normalization by means of an "artificial endocrine pancreas" on the concentrations of growth hormone, glucagon, and cortisol in juvenile diabetics. Hormone and Metabolic Research. Supplement Series, (8), pp. 93-6.
Schock A, et al. The Effect of Three Days of Blood Glucose Normalization By Means of an "artificial Endocrine Pancreas" On the Concentrations of Growth Hormone, Glucagon, and Cortisol in Juvenile Diabetics. Horm Metab Res Suppl. 1979;(8)93-6. PubMed PMID: 395097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of three days of blood glucose normalization by means of an "artificial endocrine pancreas" on the concentrations of growth hormone, glucagon, and cortisol in juvenile diabetics. AU - Schock,A, AU - Schultz,M, AU - Kerner,W, AU - Maier,V, AU - Pfeiffer,E F, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 93 EP - 6 JF - Hormone and metabolic research. Supplement series JO - Horm. Metab. Res. Suppl. IS - 8 N2 - Glucagon, growth hormone, and cortisol secretion was studied in seven male insulin-dependent diabetics under conventional subcutaneous insulin therapy and after three days of blood glucose normalization attained by the artificial endocrine pancreas (Biostator-GCIIS). The diurnal hormonal profiles under the two types of therapy were compared. Six healthy male students served as control group. A three-day period of blood glucose normalization in insulin-dependent diabetic can restore glucagon secretion to normal. Growth hormone secretion is decreased but not completely normalised. Cortisol secretion is slightly decreased. It is concluded that prolonged normoglycemia achieved by means of an artificial endocrine pancreas may completely control endocrine abnormalities in insulin-dependent diabetics. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/395097/abstract/The_effect_of_three_days_of_blood_glucose_normalization_by_means_of_an_"artificial_endocrine_pancreas"_on_the_concentrations_of_growth_hormone_glucagon_and_cortisol_in_juvenile_diabetic L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -