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The effect of three days of blood glucose normalization by means of an "artificial endocrine pancreas" on the concentrations of growth hormone, glucagon, and cortisol in juvenile diabetics.

Abstract

Glucagon, growth hormone, and cortisol secretion was studied in seven male insulin-dependent diabetics under conventional subcutaneous insulin therapy and after three days of blood glucose normalization attained by the artificial endocrine pancreas (Biostator-GCIIS). The diurnal hormonal profiles under the two types of therapy were compared. Six healthy male students served as control group. A three-day period of blood glucose normalization in insulin-dependent diabetic can restore glucagon secretion to normal. Growth hormone secretion is decreased but not completely normalised. Cortisol secretion is slightly decreased. It is concluded that prolonged normoglycemia achieved by means of an artificial endocrine pancreas may completely control endocrine abnormalities in insulin-dependent diabetics.

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    MeSH

    Adult
    Artificial Organs
    Blood Glucose
    Circadian Rhythm
    Diabetes Mellitus, Type 1
    Feedback
    Glucagon
    Growth Hormone
    Humans
    Hydrocortisone
    Infusions, Parenteral
    Insulin
    Islets of Langerhans
    Middle Aged

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    395097

    Citation

    TY - JOUR T1 - The effect of three days of blood glucose normalization by means of an "artificial endocrine pancreas" on the concentrations of growth hormone, glucagon, and cortisol in juvenile diabetics. AU - Schock,A, AU - Schultz,M, AU - Kerner,W, AU - Maier,V, AU - Pfeiffer,E F, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 93 EP - 6 JF - Hormone and metabolic research. Supplement series JO - Horm. Metab. Res. Suppl. IS - 8 N2 - Glucagon, growth hormone, and cortisol secretion was studied in seven male insulin-dependent diabetics under conventional subcutaneous insulin therapy and after three days of blood glucose normalization attained by the artificial endocrine pancreas (Biostator-GCIIS). The diurnal hormonal profiles under the two types of therapy were compared. Six healthy male students served as control group. A three-day period of blood glucose normalization in insulin-dependent diabetic can restore glucagon secretion to normal. Growth hormone secretion is decreased but not completely normalised. Cortisol secretion is slightly decreased. It is concluded that prolonged normoglycemia achieved by means of an artificial endocrine pancreas may completely control endocrine abnormalities in insulin-dependent diabetics. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/395097/abstract/The_effect_of_three_days_of_blood_glucose_normalization_by_means_of_an_"artificial_endocrine_pancreas"_on_the_concentrations_of_growth_hormone_glucagon_and_cortisol_in_juvenile_diabetic L2 - http://www.labome.org//expert/usa/case/delgado/pedro-l-delgado-395097.html ER -