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Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol.
N Engl J Med. 1986 Mar 20; 314(12):745-8.NEJM

Abstract

To examine the effects of dietary fatty acids and carbohydrate on plasma lipids and lipoproteins, 11 patients with a mean plasma total cholesterol level of 251 +/- 10 mg per deciliter were studied on a metabolic ward during three dietary periods, each lasting four weeks. A liquid diet rich in monounsaturated fatty acids ("High-Mono") and a diet low in fat ("Low-Fat") were compared with a diet high in saturated fatty acids ("High-Sat"). The High-Sat and High-Mono diets contained 40 percent of their total calories as fat and 43 percent as carbohydrate; the Low-Fat diet had 20 percent fat and 63 percent carbohydrate. Body weight was kept constant by adjusting total caloric intake. As compared with the High-Sat diet, both the High-Mono and Low-Fat diets lowered plasma total cholesterol (by 13 percent and 8 percent, respectively) and low-density lipoprotein cholesterol (by 21 percent and 15 percent, respectively). As compared with the High-Sat diet, the Low-Fat diet raised triglyceride levels and significantly reduced plasma high-density lipoprotein cholesterol. In contrast, the High-Mono diet had no effect on levels of triglycerides or high-density lipoprotein cholesterol. The ratio of low-density to high-density lipoprotein cholesterol was also significantly lower when the High-Mono diet rather than the Low-Fat diet was followed. Therefore, in short-term studies in which liquid diets are used and body weight is kept constant, a diet rich in monounsaturated fatty acids appears to be at least as effective in lowering plasma cholesterol as a diet low in fat and high in carbohydrate.

Authors

No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3951504

Citation

Grundy, S M.. "Comparison of Monounsaturated Fatty Acids and Carbohydrates for Lowering Plasma Cholesterol." The New England Journal of Medicine, vol. 314, no. 12, 1986, pp. 745-8.
Grundy SM. Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. N Engl J Med. 1986;314(12):745-8.
Grundy, S. M. (1986). Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. The New England Journal of Medicine, 314(12), 745-8.
Grundy SM. Comparison of Monounsaturated Fatty Acids and Carbohydrates for Lowering Plasma Cholesterol. N Engl J Med. 1986 Mar 20;314(12):745-8. PubMed PMID: 3951504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of monounsaturated fatty acids and carbohydrates for lowering plasma cholesterol. A1 - Grundy,S M, PY - 1986/3/20/pubmed PY - 1986/3/20/medline PY - 1986/3/20/entrez SP - 745 EP - 8 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 314 IS - 12 N2 - To examine the effects of dietary fatty acids and carbohydrate on plasma lipids and lipoproteins, 11 patients with a mean plasma total cholesterol level of 251 +/- 10 mg per deciliter were studied on a metabolic ward during three dietary periods, each lasting four weeks. A liquid diet rich in monounsaturated fatty acids ("High-Mono") and a diet low in fat ("Low-Fat") were compared with a diet high in saturated fatty acids ("High-Sat"). The High-Sat and High-Mono diets contained 40 percent of their total calories as fat and 43 percent as carbohydrate; the Low-Fat diet had 20 percent fat and 63 percent carbohydrate. Body weight was kept constant by adjusting total caloric intake. As compared with the High-Sat diet, both the High-Mono and Low-Fat diets lowered plasma total cholesterol (by 13 percent and 8 percent, respectively) and low-density lipoprotein cholesterol (by 21 percent and 15 percent, respectively). As compared with the High-Sat diet, the Low-Fat diet raised triglyceride levels and significantly reduced plasma high-density lipoprotein cholesterol. In contrast, the High-Mono diet had no effect on levels of triglycerides or high-density lipoprotein cholesterol. The ratio of low-density to high-density lipoprotein cholesterol was also significantly lower when the High-Mono diet rather than the Low-Fat diet was followed. Therefore, in short-term studies in which liquid diets are used and body weight is kept constant, a diet rich in monounsaturated fatty acids appears to be at least as effective in lowering plasma cholesterol as a diet low in fat and high in carbohydrate. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/3951504/Comparison_of_monounsaturated_fatty_acids_and_carbohydrates_for_lowering_plasma_cholesterol_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM198603203141204?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -