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Long-term stability study of histamine in sterile bronchoprovocation solutions.
Am J Hosp Pharm. 1986 Feb; 43(2):380-3.AJ

Abstract

The long-term stability of histamine in sterile bronchoprovocation solutions stored under different conditions was studied. Histamine solutions (2 and 8 mg/mL) were stored in specially adapted translucent and black plastic bottles and kept in a cool place (12 degrees C) and exposed to fluorescent light (500 foot-candles intensity). Multiple aliquots of each concentration were also stored at -20 degrees C in 12 X 75 mm sterile polypropylene tubes with snap caps and covered with aluminum foil. The content of histamine in the stored samples was determined by a stability-indicating colorimetric assay. The histamine solutions were stable for up to eight months at 12 degrees C when stored in either of the specially adapted translucent or black plastic bottles, irrespective of normal long-term exposure to fluorescent light. No important changes were observed in the histamine concentration when these solutions were stored at -20 degrees C in polypropylene tubes for up to a year. Histamine solutions used in bronchoprovocation tests can be stored in plastic bottles in a cool place or in the refrigerator. It is not necessary to protect these solutions from normal long-term exposures to fluorescent light to ensure clinically acceptable stability.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3953600

Citation

Marwaha, R K., and B F. Johnson. "Long-term Stability Study of Histamine in Sterile Bronchoprovocation Solutions." American Journal of Hospital Pharmacy, vol. 43, no. 2, 1986, pp. 380-3.
Marwaha RK, Johnson BF. Long-term stability study of histamine in sterile bronchoprovocation solutions. Am J Hosp Pharm. 1986;43(2):380-3.
Marwaha, R. K., & Johnson, B. F. (1986). Long-term stability study of histamine in sterile bronchoprovocation solutions. American Journal of Hospital Pharmacy, 43(2), 380-3.
Marwaha RK, Johnson BF. Long-term Stability Study of Histamine in Sterile Bronchoprovocation Solutions. Am J Hosp Pharm. 1986;43(2):380-3. PubMed PMID: 3953600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term stability study of histamine in sterile bronchoprovocation solutions. AU - Marwaha,R K, AU - Johnson,B F, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 380 EP - 3 JF - American journal of hospital pharmacy JO - Am J Hosp Pharm VL - 43 IS - 2 N2 - The long-term stability of histamine in sterile bronchoprovocation solutions stored under different conditions was studied. Histamine solutions (2 and 8 mg/mL) were stored in specially adapted translucent and black plastic bottles and kept in a cool place (12 degrees C) and exposed to fluorescent light (500 foot-candles intensity). Multiple aliquots of each concentration were also stored at -20 degrees C in 12 X 75 mm sterile polypropylene tubes with snap caps and covered with aluminum foil. The content of histamine in the stored samples was determined by a stability-indicating colorimetric assay. The histamine solutions were stable for up to eight months at 12 degrees C when stored in either of the specially adapted translucent or black plastic bottles, irrespective of normal long-term exposure to fluorescent light. No important changes were observed in the histamine concentration when these solutions were stored at -20 degrees C in polypropylene tubes for up to a year. Histamine solutions used in bronchoprovocation tests can be stored in plastic bottles in a cool place or in the refrigerator. It is not necessary to protect these solutions from normal long-term exposures to fluorescent light to ensure clinically acceptable stability. SN - 0002-9289 UR - https://www.unboundmedicine.com/medline/citation/3953600/Long_term_stability_study_of_histamine_in_sterile_bronchoprovocation_solutions_ DB - PRIME DP - Unbound Medicine ER -
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