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Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase.
Biochem J. 1979 Apr 15; 180(1):153-60.BJ

Abstract

Liver of rat foetuses from 14 to 19 days of gestation and cultured hepatocytes derived from foetuses of 14 or 15 days gestation show a limited capacity to transaminate tyrosine. This low tyrosine transamination activity can be ascribed to aspartate aminotransferase. Definitive tyrosine aminotransferase can be demonstrated in 1-day-old cultures of hepatocytes taken from 19-day foetuses, but not from 15-day foetuses. However, after 3 days of culture hepatocytes from 15-day foetuses are able to synthesize tyrosine aminotransferase. Induction studies reveal that dexamethasone is capable of increasing tyrosine aminotransferase activity once it is detectable in culture.

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Authors

Yeoh GC
No affiliation info available
Bennett FA
No affiliation info available
Oliver IT
No affiliation info available

MeSH

AnimalsCell DifferentiationCells, CulturedChromatography, GelDexamethasoneLiverRatsTyrosine Transaminase

Pub Type(s)

Journal Article

Language

eng

PubMed ID

39544

Citation

Yeoh, G C., et al. "Hepatocyte Differentiation in Culture. Appearance of Tyrosine Aminotransferase." The Biochemical Journal, vol. 180, no. 1, 1979, pp. 153-60.
Yeoh GC, Bennett FA, Oliver IT. Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase. Biochem J. 1979;180(1):153-60.
Yeoh, G. C., Bennett, F. A., & Oliver, I. T. (1979). Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase. The Biochemical Journal, 180(1), 153-60.
Yeoh GC, Bennett FA, Oliver IT. Hepatocyte Differentiation in Culture. Appearance of Tyrosine Aminotransferase. Biochem J. 1979 Apr 15;180(1):153-60. PubMed PMID: 39544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase. AU - Yeoh,G C, AU - Bennett,F A, AU - Oliver,I T, PY - 1979/4/15/pubmed PY - 1979/4/15/medline PY - 1979/4/15/entrez SP - 153 EP - 60 JF - The Biochemical journal JO - Biochem J VL - 180 IS - 1 N2 - Liver of rat foetuses from 14 to 19 days of gestation and cultured hepatocytes derived from foetuses of 14 or 15 days gestation show a limited capacity to transaminate tyrosine. This low tyrosine transamination activity can be ascribed to aspartate aminotransferase. Definitive tyrosine aminotransferase can be demonstrated in 1-day-old cultures of hepatocytes taken from 19-day foetuses, but not from 15-day foetuses. However, after 3 days of culture hepatocytes from 15-day foetuses are able to synthesize tyrosine aminotransferase. Induction studies reveal that dexamethasone is capable of increasing tyrosine aminotransferase activity once it is detectable in culture. SN - 0264-6021 UR - https://www.unboundmedicine.com/medline/citation/39544/Hepatocyte_differentiation_in_culture__Appearance_of_tyrosine_aminotransferase_ L2 - https://portlandpress.com/biochemj/article-lookup/doi/10.1042/bj1800153 DB - PRIME DP - Unbound Medicine ER -