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Occurrence of elevated protoporphyrin levels in relation to lead burden in infants.
Environ Res. 1986 Apr; 39(2):253-7.ER

Abstract

Simultaneous blood lead (PbB), erythrocyte protoporphyrin (EP), and hematocrit measurements were made semiannually in 232 normal infants from 6 to 24 months of age. The PbB averaged 7 (SD = 5) and ranged from 0 to 64 micrograms/dl. The incidence of elevated EP, a marker for deranged heme synthesis, was unrelated to PbB at levels below 15 micrograms/dl but was fourfold greater among the infants with PbB above 15 micrograms/dl. This relationship persisted even after eliminating the 31 (4%) anemic (hematocrit less than 33%) samples. The confounding effects of iron deficiency are discussed.

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Publisher Full Text

Authors

Rabinowitz MB
No affiliation info available
Leviton A
No affiliation info available
Needleman HL
No affiliation info available

MeSH

Child, PreschoolErythrocytesHematocritHemeHumansInfantLead PoisoningPorphyrinsProtoporphyrins

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3956457

Citation

Rabinowitz, M B., et al. "Occurrence of Elevated Protoporphyrin Levels in Relation to Lead Burden in Infants." Environmental Research, vol. 39, no. 2, 1986, pp. 253-7.
Rabinowitz MB, Leviton A, Needleman HL. Occurrence of elevated protoporphyrin levels in relation to lead burden in infants. Environ Res. 1986;39(2):253-7.
Rabinowitz, M. B., Leviton, A., & Needleman, H. L. (1986). Occurrence of elevated protoporphyrin levels in relation to lead burden in infants. Environmental Research, 39(2), 253-7.
Rabinowitz MB, Leviton A, Needleman HL. Occurrence of Elevated Protoporphyrin Levels in Relation to Lead Burden in Infants. Environ Res. 1986;39(2):253-7. PubMed PMID: 3956457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Occurrence of elevated protoporphyrin levels in relation to lead burden in infants. AU - Rabinowitz,M B, AU - Leviton,A, AU - Needleman,H L, PY - 1986/4/1/pubmed PY - 1986/4/1/medline PY - 1986/4/1/entrez SP - 253 EP - 7 JF - Environmental research JO - Environ Res VL - 39 IS - 2 N2 - Simultaneous blood lead (PbB), erythrocyte protoporphyrin (EP), and hematocrit measurements were made semiannually in 232 normal infants from 6 to 24 months of age. The PbB averaged 7 (SD = 5) and ranged from 0 to 64 micrograms/dl. The incidence of elevated EP, a marker for deranged heme synthesis, was unrelated to PbB at levels below 15 micrograms/dl but was fourfold greater among the infants with PbB above 15 micrograms/dl. This relationship persisted even after eliminating the 31 (4%) anemic (hematocrit less than 33%) samples. The confounding effects of iron deficiency are discussed. SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/3956457/Occurrence_of_elevated_protoporphyrin_levels_in_relation_to_lead_burden_in_infants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(86)80051-2 DB - PRIME DP - Unbound Medicine ER -