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Paraganglioma of the cauda equina: a histological, ultrastructural and immunocytochemical study of two cases with a review of the literature.
J Pathol. 1985 Feb; 145(2):195-201.JP

Abstract

The clinical and pathological features of two paragangliomas arising in the cauda equina are described and compared with 14 previous reports. The light microscopic features were similar to those of paragangliomas from other sites, with a 'Zellballen' pattern of cells containing argyrophil granules. Electron microscopy showed densely staining membrane-bound granules, cilia and fibrous bodies in the cytoplasm. The last two features only occur in paragangliomas from this site. gamma-Enolase was demonstrated by the peroxidase-antiperoxidase technique for the first time in these neoplasms. This technique was also used to demonstrate cytokeratins, which appear to be associated with the presence of fibrous bodies. The pathological findings suggest that paragangliomas in this site arise from pre-existing paraganglia, possibly of the visceral autonomic group. The prognosis in cases treated by complete excision appears to be good.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3973771

Citation

Ironside, J W., et al. "Paraganglioma of the Cauda Equina: a Histological, Ultrastructural and Immunocytochemical Study of Two Cases With a Review of the Literature." The Journal of Pathology, vol. 145, no. 2, 1985, pp. 195-201.
Ironside JW, Royds JA, Taylor CB, et al. Paraganglioma of the cauda equina: a histological, ultrastructural and immunocytochemical study of two cases with a review of the literature. J Pathol. 1985;145(2):195-201.
Ironside, J. W., Royds, J. A., Taylor, C. B., & Timperley, W. R. (1985). Paraganglioma of the cauda equina: a histological, ultrastructural and immunocytochemical study of two cases with a review of the literature. The Journal of Pathology, 145(2), 195-201.
Ironside JW, et al. Paraganglioma of the Cauda Equina: a Histological, Ultrastructural and Immunocytochemical Study of Two Cases With a Review of the Literature. J Pathol. 1985;145(2):195-201. PubMed PMID: 3973771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraganglioma of the cauda equina: a histological, ultrastructural and immunocytochemical study of two cases with a review of the literature. AU - Ironside,J W, AU - Royds,J A, AU - Taylor,C B, AU - Timperley,W R, PY - 1985/2/1/pubmed PY - 1985/2/1/medline PY - 1985/2/1/entrez SP - 195 EP - 201 JF - The Journal of pathology JO - J Pathol VL - 145 IS - 2 N2 - The clinical and pathological features of two paragangliomas arising in the cauda equina are described and compared with 14 previous reports. The light microscopic features were similar to those of paragangliomas from other sites, with a 'Zellballen' pattern of cells containing argyrophil granules. Electron microscopy showed densely staining membrane-bound granules, cilia and fibrous bodies in the cytoplasm. The last two features only occur in paragangliomas from this site. gamma-Enolase was demonstrated by the peroxidase-antiperoxidase technique for the first time in these neoplasms. This technique was also used to demonstrate cytokeratins, which appear to be associated with the presence of fibrous bodies. The pathological findings suggest that paragangliomas in this site arise from pre-existing paraganglia, possibly of the visceral autonomic group. The prognosis in cases treated by complete excision appears to be good. SN - 0022-3417 UR - https://www.unboundmedicine.com/medline/citation/3973771/Paraganglioma_of_the_cauda_equina:_a_histological_ultrastructural_and_immunocytochemical_study_of_two_cases_with_a_review_of_the_literature_ L2 - https://doi.org/10.1002/path.1711450207 DB - PRIME DP - Unbound Medicine ER -